Insights into FACT in Cancers with Targeted Therapeutic Implications.

Abstract

Facilitates chromatin transcription (FACT) is an evolutionarily conserved chromatin remodeling factor. It controls chromatin states in an ATP-independent manner via the regulation of chromatin assembly and disassembly. Through such regulation, FACT is involved in controlling transcription and other DNA-transacting processes such as replication and repair. However, it is surprisingly found to be upregulated in various cancers, and upregulated FACT induces oncogenesis and supports cancer cell survival, aggressiveness and metastasis, thus implying it to be a prognostic marker for cancer with an attractive targeted therapeutic potential. Here, we describe the involvement of FACT in various cancers with mechanistic insights and potential targeted therapeutic implications.