Correlation Analysis Between Immune Status and Bronchoscopic Airway Findings in Various Ages of SMPP Children.

IF 2.1 4区医学 Q3 RESPIRATORY SYSTEM

Canadian respiratory journal Pub Date : 2026-01-01 DOI:10.1155/carj/6145605

Peng Li, Ruiyang Sun, Jiapu Hou, Zewen Ding, Wanyu Jia, Shuqin Fu, Junhao Cui, Chunlan Song

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引用次数: 0

Abstract

Objective: To investigate the correlation between trends in immune markers and airway mucosal changes in SMPP by controlling for age.

Study design: A total of 302 children with SMPP admitted to Henan Children's Hospital from 2018 to 2024 were selected as the study subjects for retrospective analysis, while 133 children with GMPP were selected as the control group. The children were divided into infancy groups, toddler groups, preschool age groups, and school age groups according to their ages.

Results: (1) There were significant differences in some clinical manifestations and laboratory hematological indices among SMPP children of various ages. (2) In the SMPP group, compared to toddlers and preschool children, school-aged children had a higher rate of mucosal erosion, and compared to infants, school-aged children had a higher rate of mucous plug blockage (p < 0.05). (3) Pearson correlation analysis revealed that IgM was positively correlated with mucosal erosion and mucous plug plugging, the AGR was negatively correlated with mucosal erosion and mucous plug plugging, and the NLR and D-D were positively correlated with mucous plug plugging in preschool-aged and school-aged children. IgA and FIB were positively correlated with mucous plug blockage, and FIB was positively correlated with mucosal erosion in school-aged children with SMPP (p < 0.05).

Conclusion: IgM, IgA, NLR, AGR, FIB, and D-D in preschool-aged and school-aged children with MP infection are potential markers of disease severity and the degree of airway mucosal damage.

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不同年龄SMPP患儿免疫状态与支气管镜下气道表现的相关性分析。

目的：在控制年龄的情况下，探讨SMPP患者免疫指标变化趋势与气道黏膜变化的相关性。研究设计：选取2018 - 2024年在河南省儿童医院住院的302例SMPP患儿作为研究对象进行回顾性分析，133例GMPP患儿作为对照组。孩子们根据年龄分为婴儿组、学步组、学龄前组和学龄组。结果：(1)不同年龄的SMPP患儿在部分临床表现和血液学实验室指标上存在显著差异。(2)在SMPP组中，学龄儿童的粘膜糜烂率高于幼儿和学龄前儿童，学龄儿童的粘膜堵塞率高于婴幼儿（p < 0.05）。(3) Pearson相关分析显示，学龄前和学龄儿童IgM与粘膜糜烂和粘膜堵塞正相关，AGR与粘膜糜烂和粘膜堵塞负相关，NLR和D-D与粘膜堵塞正相关。学龄期SMPP患儿IgA、FIB与黏膜堵塞正相关，FIB与黏膜糜烂正相关（p < 0.05）。结论：学龄前和学龄MP感染儿童IgM、IgA、NLR、AGR、FIB、D-D是疾病严重程度和气道黏膜损害程度的潜在指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian respiratory journal 医学-呼吸系统

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.