The GALENOS approach to triangulating evidence: a structured approach for integrating information from human and animal studies.

IF 3.7 3区医学 Q1 HEALTH CARE SCIENCES & SERVICES

BMC Medical Research Methodology Pub Date : 2026-06-02 DOI:10.1186/s12874-026-02891-4

Thomy Tonia, Julian P T Higgins, Virginia Chiocchia, James Downs, Emily Wheeler, Jennifer Potts, Katharine A Smith, Malcolm Macleod, Gin S Malhi, Andrea Cipriani, Georgia Salanti

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引用次数: 0

Abstract

Background: Most decision-making research involves collating multiple types of evidence, and such integration should be a core component of investigative practice in science. Triangulation is one formal approach that has proven effective, typically drawing on sources of evidence with different biases. However, there remains no standardised method for its implementation and no clear guidance on how to apply triangulation in research contexts-particularly when synthesising evidence across human and animal data.

Methods: GALENOS (Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis) has introduced GATE (GALENOS Approach to Triangulating Evidence), a multifaceted framework for such triangulation. To further develop GATE, we here systematically searched the literature for work describing triangulation processes for human and animal data.

Results: As a key component of GATE, we provide conceptual details and practical guidance on how to prepare, organise, conduct, and follow up on triangulation meetings.

Conclusions: Based on findings from this literature and our experience with GATE, we updated our approach.

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三角测量证据的GALENOS方法：一种整合人类和动物研究信息的结构化方法。

背景：大多数决策研究涉及整理多种类型的证据，这种整合应该是科学调查实践的核心组成部分。三角测量是一种被证明有效的正式方法，通常利用不同偏见的证据来源。然而，它的实施仍然没有标准化的方法，也没有关于如何在研究环境中应用三角测量的明确指导——特别是在综合人类和动物数据的证据时。方法：GALENOS（全球焦虑、抑郁和精神病活证据联盟）引入了GATE (GALENOS Approach to triangulation Evidence)，这是一个多层面的三角测量框架。为了进一步发展GATE，我们在这里系统地检索了描述人类和动物数据三角测量过程的文献。结果：作为GATE的关键组成部分，我们提供关于如何准备、组织、进行和跟进三角测量会议的概念细节和实践指导。结论：基于这些文献的发现和我们在GATE的经验，我们更新了我们的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Research Methodology 医学-卫生保健

CiteScore

6.50

自引率

2.50%

发文量

298

审稿时长

3-8 weeks

期刊介绍： BMC Medical Research Methodology is an open access journal publishing original peer-reviewed research articles in methodological approaches to healthcare research. Articles on the methodology of epidemiological research, clinical trials and meta-analysis/systematic review are particularly encouraged, as are empirical studies of the associations between choice of methodology and study outcomes. BMC Medical Research Methodology does not aim to publish articles describing scientific methods or techniques: these should be directed to the BMC journal covering the relevant biomedical subject area.