[Research progress on the role of tertiary lymphoid structures in the perioperative comprehensive therapy of biliary tract cancer].

中华外科杂志 Pub Date : 2026-07-01 DOI:10.3760/cma.j.cn112139-20251102-00511

X L Zhou, D L Qin, Z L Li, J L Chen, Y Tang, Z H Tang, Z W Quan

引用次数: 0

Abstract

Tertiary lymphoid structures (TLS), which are ectopic lymphocyte aggregates formed during chronic inflammation, are widely present in the tumor microenvironment of solid malignancies. By regulating anti-tumor immune responses, TLS is increasingly recognized as a key focus in cancer therapeutic research. However, systematic investigations into its role in biliary tract cancer (BTC) remain scarce. This essay outlines the fundamental characteristics, heterogeneity, and prognostic significance of TLS, and explores its potential role in perioperative comprehensive treatment and therapy sensitivity assessment for BTC. It provides novel perspectives and a theoretical foundation for TLS-guided precision therapy in biliary tract cancer.

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[三级淋巴结构在胆道癌围手术期综合治疗中的作用研究进展]。

三级淋巴样结构（TLS）是慢性炎症过程中形成的异位淋巴细胞聚集体，广泛存在于实体恶性肿瘤的肿瘤微环境中。通过调节抗肿瘤免疫反应，TLS越来越被认为是癌症治疗研究的重点。然而，关于其在胆道癌（BTC）中的作用的系统研究仍然很少。本文概述了TLS的基本特征、异质性和预后意义，并探讨了其在BTC围手术期综合治疗和治疗敏感性评估中的潜在作用。为tls引导下胆道肿瘤的精准治疗提供了新的视角和理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华外科杂志

CiteScore

0.80

自引率

0.00%

发文量

20861

期刊介绍： Chinese Journal of Surgery|Chin J Surg (monthly) is a high-level medical science and technology journal approved by the General Administration of Press and Publication of the People's Republic of China, under the supervision of the China Association for Science and Technology, and organised by the Chinese Medical Association for domestic and international public circulation. It was founded in January 1951, and is published on the basis of the Journal of Chinese Surgery. The Journal is aimed at senior and intermediate surgeons and related researchers, mainly reporting the leading scientific research results and clinical experience in the field of surgery, as well as the basic theoretical research that has a guiding effect on the clinical work of surgery. Chinese Journal of Surgery|Chin J Surg is committed to reflecting the major research progress in the field of surgery in China and promoting academic exchanges at home and abroad. The main columns include thesis, meta-analysis, review, expert forum, synthesis, case report, diagnosis and treatment experience, technical exchange, clinical case discussion, academic controversy, and special lectures, etc. The journal has been accepted by the National Academy of Medicine of the United States. The journal has been included in many famous databases at home and abroad, such as the Biomedical Analysis and Online Retrieval System (MEDLINE) of the U.S. National Library of Medicine.