Clinical Relevance and Utility of Serum APOC2 Levels in Patients with Type 2 Diabetes Mellitus: A Comparative Study on Subjects with and without Pyogenic Liver Abscess.
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Abstract
Purpose: To investigate the diagnostic value of serum APOC2 in patients with diabetes mellitus combined with pyogenic liver abscess.
Methods: From April 2023 to July 2023, 77 type 2 diabetes mellitus patients were included which divided into two groups: diabetes mellitus (n=55) and diabetes mellitus combined with pyogenic liver abscess (n=22). Additionally, 27 healthy individuals served as the control group. Serum APOC2 levels were detected and compared among the groups. ROC curve and logistic regression analysis were performed to evaluate the diagnostic value of serum APOC2.
Results: Serum APOC2 levels were significantly higher in diabetes mellitus patients compared to the healthy control group (P=0.008). In diabetes mellitus combined with pyogenic liver abscess patients, APOC2 levels were significantly reduced (P<0.001) while increased post-treatment (P<0.001). ROC curve analysis showed high diagnostic accuracy for serum APOC2 in diabetes mellitus combined with pyogenic liver abscess (AUC=0.945). Logistic regression analysis revealed that reduced serum APOC2 levels were a risk factor for diabetes mellitus combined with pyogenic liver abscess (OR=0.02, 95% CI=0.01~0.16, P=0.012). The diabetes mellitus combined with pyogenic liver abscess patients with lower APOC2 levels had higher ALT (P=0.038) and AST levels (P=0.007), suggesting that reduced serum APOC2 levels were associated with liver damage.
Conclusion: Serum APOC2 levels are significantly decreased in patients with diabetes mellitus combined with pyogenic liver abscess, serving as a potential marker for predicting the occurrence of this condition. Lower levels of APOC2 are strongly linked to liver function impairment.
期刊介绍：
Hepatic Medicine: Evidence and Research is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of adult and pediatric hepatology in the clinic and laboratory including the following topics: Pathology, pathophysiology of hepatic disease Investigation and treatment of hepatic disease Pharmacology of drugs used for the treatment of hepatic disease Although the main focus of the journal is to publish research and clinical results in humans; preclinical, animal and in vitro studies will be published where they will shed light on disease processes and potential new therapies. Issues of patient safety and quality of care will also be considered. As of 1st April 2019, Hepatic Medicine: Evidence and Research will no longer consider meta-analyses for publication.
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