Accuracy and Reliability of Radiometer Gas Analyzer for Neonatal Hyperbilirubinaemia Management.

Q3 Medicine

Irish medical journal Pub Date : 2026-05-21

V Bell, L Pentony, G M Mineva, S L Naidu, H Rafaqat, S Cavallari, P Penrose, M Ahmed, J Altaf, I Roze, M Elsammak, J D Corcoran

{"title":"Accuracy and Reliability of Radiometer Gas Analyzer for Neonatal Hyperbilirubinaemia Management.","authors":"V Bell, L Pentony, G M Mineva, S L Naidu, H Rafaqat, S Cavallari, P Penrose, M Ahmed, J Altaf, I Roze, M Elsammak, J D Corcoran","doi":"","DOIUrl":null,"url":null,"abstract":"Aims: To assess the accuracy of capillary gas bilirubin (Radiometer TBiL) compared to venous total plasma bilirubin (Roche TPB), and to evaluate the reliability of Radiometer TBiL in neonatal hyperbilirubinaemia treatment decisions.Methods: A prospective study was conducted at a tertiary neonatal centre in Dublin, Ireland between December 2023 and May 2025. Paired Radiometer TBiL and Roche TPB measurements were obtained from 97 neonates requiring bilirubin assessment.Results: Radiometer TBiL demonstrated high correlation with Roche TPB (r = 0.97, p < 0.0001), although Radiometer TBiL showed an overestimation, especially at bilirubin levels between 150 to 230 µmol/L. Bland-Altman analysis revealed a mean difference of -16.6 µmol/L with wide limits of agreement (-63.6 to 30.4 µmol/L). Kappa analysis (κ = 0.35, 95% CI: 0.14 - 0.55) showed fair agreement in treatment decisions, with a tendency for Radiometer TBiL to overestimate the need for treatment, but there was no significant underestimation.Discussion: Radiometer TBiL offers a rapid and less invasive alternative for bilirubin screening and risk stratification in neonates, with high correlation to standard laboratory measurements. While a tendency to overestimate bilirubin levels may lead to overtreatment, the absence of significant underestimation suggests Radiometer TBiL is a safe tool for clinical decision-making. Larger studies are warranted to validate these findings and refine clinical thresholds.","PeriodicalId":14713,"journal":{"name":"Irish medical journal","volume":"119 5","pages":"83"},"PeriodicalIF":0.0000,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Irish medical journal","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: To assess the accuracy of capillary gas bilirubin (Radiometer TBiL) compared to venous total plasma bilirubin (Roche TPB), and to evaluate the reliability of Radiometer TBiL in neonatal hyperbilirubinaemia treatment decisions.

Methods: A prospective study was conducted at a tertiary neonatal centre in Dublin, Ireland between December 2023 and May 2025. Paired Radiometer TBiL and Roche TPB measurements were obtained from 97 neonates requiring bilirubin assessment.

Results: Radiometer TBiL demonstrated high correlation with Roche TPB (r = 0.97, p < 0.0001), although Radiometer TBiL showed an overestimation, especially at bilirubin levels between 150 to 230 µmol/L. Bland-Altman analysis revealed a mean difference of -16.6 µmol/L with wide limits of agreement (-63.6 to 30.4 µmol/L). Kappa analysis (κ = 0.35, 95% CI: 0.14 - 0.55) showed fair agreement in treatment decisions, with a tendency for Radiometer TBiL to overestimate the need for treatment, but there was no significant underestimation.

Discussion: Radiometer TBiL offers a rapid and less invasive alternative for bilirubin screening and risk stratification in neonates, with high correlation to standard laboratory measurements. While a tendency to overestimate bilirubin levels may lead to overtreatment, the absence of significant underestimation suggests Radiometer TBiL is a safe tool for clinical decision-making. Larger studies are warranted to validate these findings and refine clinical thresholds.

本刊更多论文

辐射计气体分析仪在新生儿高胆红素血症管理中的准确性和可靠性。

目的：评价毛细管气体胆红素（Radiometer TBiL）与静脉总血浆胆红素（Roche TPB）的准确性，并评价Radiometer TBiL在新生儿高胆红素血症治疗决策中的可靠性。方法：一项前瞻性研究于2023年12月至2025年5月在爱尔兰都柏林的一家三级新生儿中心进行。配对辐射计TBiL和罗氏TPB测量从需要评估胆红素的97名新生儿中获得。结果：Radiometer TBiL与Roche TPB高度相关（r = 0.97, p < 0.0001），尽管Radiometer TBiL显示出高估，特别是在胆红素水平在150至230µmol/L之间时。Bland-Altman分析显示，平均差异为-16.6µmol/L，一致性范围很广（-63.6至30.4µmol/L）。Kappa分析（κ = 0.35, 95% CI: 0.14 - 0.55）显示治疗决策的一致性，Radiometer TBiL倾向于高估治疗需求，但没有显著低估。讨论：辐射计TBiL为新生儿胆红素筛查和风险分层提供了一种快速且侵入性较小的替代方法，与标准实验室测量结果高度相关。虽然过高估计胆红素水平的倾向可能导致过度治疗，但没有明显低估表明放射计TBiL是临床决策的安全工具。需要更大规模的研究来验证这些发现并完善临床阈值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Irish medical journal Medicine-Medicine (all)

CiteScore

1.00

自引率

0.00%

发文量

139

期刊介绍： Since its inception in 1867, the Journal of the Medical Association of Ireland and now in its present format, the Irish Medical Journal, has provided the medical community in Ireland with an invaluable service. As one of the leading biomedical publications in Ireland, it has sought to continue the education of medical students and postgraduates through scientific research, review articles and updates on contemporary clinical practices while providing an ongoing forum for medical debate. A measure of our stature is that we are listed in the Index Medicus and issued annually with a citation factor from the Institute for Scientific Information.