Diagnostic accuracy of fine-needle aspiration cytology in salivary gland neoplasms: a systematic review and meta-analysis.

IF 4.3 3区医学 Q1 PATHOLOGY

Expert Review of Molecular Diagnostics Pub Date : 2026-06-01 Epub Date: 2026-05-28 DOI:10.1080/14737159.2026.2680033

Hasmat Ali, Rezhat Abbas, Aadithya B Urs, Priya Kumar, Jeyaseelan Augustine

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引用次数: 0

Abstract

Introduction: Fine-needle aspiration cytology is a widely used minimally invasive tool for salivary gland lesions, though diagnostic challenges arise due to overlapping features between benign and malignant tumors. This systematic review and meta-analysis evaluate its diagnostic performance in salivary gland neoplasms.

Methods: A comprehensive literature search was conducted in PubMed/MEDLINE, Embase, Scopus, and Web of Science. Studies reporting sensitivity, specificity, or sufficient data to construct 2 × 2 tables were included. Data extraction was performed independently by two reviewers, and study quality was assessed using the QUADAS-2 tool. Diagnostic accuracy was pooled using a bivariate random-effects model, and summary receiver operating characteristic curves were generated. Publication bias was evaluated using Deeks' funnel plot.

Results: A total of 56 studies were included, of which 32 were eligible for meta-analysis. The pooled sensitivity of FNAC was 0.79 (95% CI: 0.75-0.83), and specificity was 0.94 (95% CI: 0.93-0.96). The summary analysis demonstrated good discriminative ability with an area under the curve of 0.89. No significant publication bias was detected.

Conclusions: FNAC demonstrates high diagnostic accuracy, with high specificity and moderate sensitivity, supporting its role as a reliable first-line diagnostic tool in salivary gland neoplasms.

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细针穿刺细胞学在唾液腺肿瘤诊断中的准确性：系统回顾和荟萃分析。

细针穿刺细胞学是一种广泛应用于唾液腺病变的微创工具，尽管由于良性和恶性肿瘤之间的重叠特征，诊断存在挑战。本系统综述和荟萃分析评估了其在唾液腺肿瘤中的诊断性能。方法：在PubMed/MEDLINE、Embase、Scopus、Web of Science中进行综合文献检索。报告敏感性、特异性或足够数据构建2 × 2表的研究被纳入。数据提取由两名审稿人独立完成，使用QUADAS-2工具评估研究质量。使用双变量随机效应模型对诊断准确性进行汇总，并生成汇总的受试者工作特征曲线。采用Deeks漏斗图评价发表偏倚。结果：共纳入56项研究，其中32项符合meta分析。FNAC的综合敏感性为0.79 (95% CI: 0.75 ~ 0.83)，特异性为0.94 （95% CI: 0.93 ~ 0.96）。结果表明，综合分析具有较好的判别能力，曲线下面积为0.89。未发现显著的发表偏倚。结论：FNAC诊断准确率高，特异性高，敏感性中等，可作为涎腺肿瘤可靠的一线诊断工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.