Medium Cut-Off Versus High-Flux Dialyzers and Changes in Beck Depression Inventory Scores in Maintenance Hemodialysis: An Exploratory Observational Study

IF 1.4 4区医学 Q3 UROLOGY & NEPHROLOGY

Hemodialysis International Pub Date : 2026-10-05 Epub Date: 2026-05-21 DOI:10.1111/hdi.70091

Fevzi Necati Avsar, Osman Erinc, Tuncay Sahutoglu

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Abstract

Introduction

Depression is prevalent in maintenance hemodialysis patients and is influenced by the interplay of physical and mental health. Rather than a direct antidepressant effect of dialyzer membrane type, improved clearance of middle and large uremic solutes may alleviate uremia-related symptoms that indirectly influence mood and quality of life.

Methods

This prospective observational study compared changes in Beck Depression Inventory (BDI) scores over 6 months between thrice-weekly hemodialysis patients treated with Theranova-400 or FX80 dialyzers.

Results

Fifty participants were included (Theranova-400/FX80: 25/25; median age 52.5 [27.7] years; 27 females; dialysis vintage 60 [86] months). The reduction in BDI scores did not differ significantly between the two groups (p = 0.203). In the within-group analysis, a significant decline was observed in the FX80 arm (−4.72 ± 6.62, p = 0.003) but not in the Theranova-400 arm (−3.20 ± 10.3, p = 0.199). However, in the subgroup of patients with baseline BDI scores > 14, both dialyzer groups showed statistically significant decreases in BDI scores (FX80: 24.7 ± 7.3 to 16.5 ± 6.6, p = 0.016; Theranova-400: 24.1 ± 8.4 to 14.8 ± 10, p = 0.037).

Conclusion

In this exploratory observational study, BDI scores decreased over 6 months in both groups; however, between-group change in BDI did not differ significantly. These findings do not support a dialyzer-specific antidepressant effect of Theranova-400 compared with FX80. Within-group changes, particularly in the FX80 arm, should be interpreted cautiously considering possible repeated-measurement effects, regression to the mean, and unmeasured confounding. Future studies should evaluate whether changes in uremic symptom burden mediate mood-related scores.

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中等临界值与高通量透析器和维持血液透析贝克抑郁量表评分的变化：一项探索性观察研究。

导读：抑郁症在维持性血液透析患者中普遍存在，并受身心健康相互作用的影响。而不是透析膜类型的直接抗抑郁作用，改善中、大尿毒症溶质的清除可能减轻尿毒症相关症状，间接影响情绪和生活质量。方法：这项前瞻性观察性研究比较了每周三次血液透析患者使用Theranova-400或FX80透析器治疗6个月后贝克抑郁量表（BDI）评分的变化。结果：纳入50例受试者（Theranova-400/FX80: 25/25，中位年龄52.5[27.7]岁，女性27例，透析时间60[86]个月）。两组间BDI评分的降低无显著差异（p = 0.203）。在组内分析中，FX80组显著下降（-4.72±6.62,p = 0.003），而Theranova-400组无显著下降（-3.20±10.3,p = 0.199）。然而，在基线BDI评分bbb14的患者亚组中，两组患者的BDI评分均有统计学意义的降低（FX80: 24.7±7.3至16.5±6.6,p = 0.016; Theranova-400: 24.1±8.4至14.8±10,p = 0.037）。结论：在这项探索性观察研究中，两组患者的BDI评分在6个月内均有所下降；BDI组间变化无显著性差异。这些发现并不支持Theranova-400与FX80相比具有透析特异性抗抑郁作用。组内变化，特别是在FX80组中，应谨慎解释，考虑到可能的重复测量效应、回归均值和未测量的混杂。未来的研究应该评估尿毒症症状负担的变化是否介导情绪相关评分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hemodialysis International UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hemodialysis International was originally an annual publication containing the Proceedings of the International Symposium on Hemodialysis held in conjunction with the Annual Dialysis Conference. Since 2003, Hemodialysis International is published quarterly and contains original papers on clinical and experimental topics related to dialysis in addition to the Annual Dialysis Conference supplement. This journal is a must-have for nephrologists, nurses, and technicians worldwide. Quarterly issues of Hemodialysis International are included with your membership to the International Society for Hemodialysis. The journal contains original articles, review articles, and commentary to keep readers completely updated in the field of hemodialysis. Edited by international and multidisciplinary experts, Hemodialysis International disseminates critical information in the field.