J Y Qiu, Y P Liu, H L Mi, Y L Yang, F Liang, H Z Fang, X T Jia, J Y Li, Y Miao
{"title":"[Epstein-Barr virus-positive nodal T/NK-cell lymphoma presenting with hemophagocytic lymphohistiocytosis: a case report and literature review].","authors":"J Y Qiu, Y P Liu, H L Mi, Y L Yang, F Liang, H Z Fang, X T Jia, J Y Li, Y Miao","doi":"10.3760/cma.j.cn121090-20250922-00431","DOIUrl":null,"url":null,"abstract":"<p><p>To enhance our understanding of Epstein-Barr virus (EBV) -positive nodal T/natural killer (NK) cell lymphoma and improve the early recognition and diagnosis of patients presenting with hemophagocytic syndrome (HLH) as the initial manifestation, this article retrospectively summarizes clinical data for a case of EBV-positive nodal T/NK cell lymphoma presenting with HLH at onset and reviews relevant literature. The patient, a 58-year-old male, presented with a \"fever for 6 days\" as the chief complaint, with the initial clinical manifestation being HLH. Despite active standard treatment, the patient died less than 2 months after diagnosis. EBV-positive nodal T/NK cell lymphoma is clinically rare and easily misdiagnosed. Most patients are diagnosed at an advanced stage. Furthermore, there is currently no standard treatment, leading to an extremely poor prognosis.</p>","PeriodicalId":24016,"journal":{"name":"Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi","volume":"47 4","pages":"383-386"},"PeriodicalIF":0.0000,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13195545/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn121090-20250922-00431","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
To enhance our understanding of Epstein-Barr virus (EBV) -positive nodal T/natural killer (NK) cell lymphoma and improve the early recognition and diagnosis of patients presenting with hemophagocytic syndrome (HLH) as the initial manifestation, this article retrospectively summarizes clinical data for a case of EBV-positive nodal T/NK cell lymphoma presenting with HLH at onset and reviews relevant literature. The patient, a 58-year-old male, presented with a "fever for 6 days" as the chief complaint, with the initial clinical manifestation being HLH. Despite active standard treatment, the patient died less than 2 months after diagnosis. EBV-positive nodal T/NK cell lymphoma is clinically rare and easily misdiagnosed. Most patients are diagnosed at an advanced stage. Furthermore, there is currently no standard treatment, leading to an extremely poor prognosis.
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