The performance of fine needle aspiration cytology (FNAC) compared to histology in the preoperative diagnosis of thyroid cancer: a single centre study.

IF 0.6 4区医学 Q4 SURGERY

South African Journal of Surgery Pub Date : 2026-03-01 DOI:10.36303/SAJS.02294

S Pillay, T Ntrama, G Muthen, C Trainer, Y Varachia, M Mmutlane, T Luvhengo, N Sishuba

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引用次数: 0

Abstract

Background: Thyroid cancer is the most common endocrine malignancy globally. Fine needle aspiration cytology (FNAC) is used in the diagnostic workup of thyroid nodules. There have been discrepancies between FNAC and histology at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). This prompted a study to determine the performance of FNAC compared to histology in diagnosing thyroid cancer at CMJAH.

Methods: A retrospective review of patients who underwent thyroid surgery at CMJAH between 1 January 2015 and 1 September 2022 was conducted. Patient details were accessed via the theatre registry and the department of nuclear medicine. FNAC and histology results were accessed using the National Health Laboratory Service (NHLS) website. The data was collected and entered into a Microsoft excel spreadsheet. STATA statistical software was used to analyse the data.

Results: A total of 369 patients were screened, of which 222 were included in the study. We found the prevalence of thyroid cancer at CMJAH to be 35.6%. FNAC was found to have a sensitivity of 83.6% and a specificity of 88.7%. Its accuracy was 0.861 and it had a PPV of 81.2% and a NPV of 90.3%. The likelihood ratio generated was 7.39. PTC was found to be the most prevalent subtype with the FNAC malignancy detection rate of 85%.

Conclusion: Our study showed that FNAC performed well in diagnosing thyroid cancer preoperatively. Therefore, it should continue to be used in the diagnostic workup of thyroid nodules at CMJAH.

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细针穿刺细胞学（FNAC）与组织学在甲状腺癌术前诊断中的比较：一项单中心研究。

背景：甲状腺癌是全球最常见的内分泌恶性肿瘤。细针穿刺细胞学（FNAC）用于甲状腺结节的诊断检查。在Charlotte Maxeke约翰内斯堡学术医院（CMJAH）的FNAC和组织学之间存在差异。这促使一项研究确定FNAC与组织学在CMJAH诊断甲状腺癌中的表现。方法：回顾性分析2015年1月1日至2022年9月1日在CMJAH接受甲状腺手术的患者。患者的详细信息可通过医院登记处和核医学部获取。FNAC和组织学结果通过国家卫生实验室服务（NHLS）网站获取。收集数据并输入微软excel电子表格。采用STATA统计软件对数据进行分析。结果：共筛选369例患者，其中222例纳入研究。我们发现CMJAH中甲状腺癌的患病率为35.6%。FNAC的敏感性为83.6%，特异性为88.7%。其准确率为0.861，PPV为81.2%，NPV为90.3%。所得似然比为7.39。PTC是最常见的亚型，FNAC恶性肿瘤检出率为85%。结论：FNAC在甲状腺癌术前诊断中有较好的应用价值。因此，它应继续用于CMJAH甲状腺结节的诊断工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

South African Journal of Surgery 医学-外科

CiteScore

0.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： The South African Journal of Surgery (SAJS) is a quarterly, general surgical journal. It carries research articles and letters, editorials, clinical practice and other surgical articles and personal opinion, South African health-related news, obituaries and general correspondence.