Targeting competitive Fe-S regulation to treat Friedreich's ataxia.

IF 24 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2026-06-01 Epub Date: 2026-05-18 DOI:10.1016/j.tips.2026.04.010

Juliane C Campos, Julio C B Ferreira

引用次数: 0

Abstract

Recent discoveries reveal that frataxin (FXN) and ferredoxin 2 (FDX2) competitively regulate mitochondrial iron-sulfur (Fe-S) cluster biosynthesis through their binding to the cysteine desulfurase NFS1 and the iron-sulfur cluster scaffold protein ISCU2 complex. Here, we discuss the potential of rationally designed peptide inhibitors targeting the FDX2-NFS1 interaction as a strategy to mitigate FXN deficiency and restore Fe-S cluster biosynthesis.

查看原文本刊更多论文

针对竞争性Fe-S调控治疗弗里德赖希共济失调。

最近的研究发现，氧化铁蛋白（FXN）和铁氧还蛋白2 （FDX2）通过与半胱氨酸脱硫酶NFS1和铁硫支架蛋白ISCU2复合物结合，竞争性地调节线粒体铁硫（Fe-S）簇的生物合成。在这里，我们讨论了合理设计肽抑制剂的潜力，靶向FDX2-NFS1相互作用，作为缓解FXN缺乏和恢复Fe-S簇生物合成的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.