A clinical study on Clitoria ternatea tea therapy to manage diabetic distress in people with type 2 diabetes.

IF 3 Q3 CHEMISTRY, MEDICINAL

Avicenna Journal of Phytomedicine Pub Date : 2026-05-01 DOI:10.22038/ajp.2025.26573

Vadivel Mani, Ramya Badrachalam, Brindha Santhnakrishnan, Muninathan Natrajan, Sangeeta Chandrashekar, Nisha Kuppan, Swapna Dileep Garikimukkala, Sadhana Undru

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Abstract

Objective: The purpose of this study was to assess the impact of supplementing with shankhpushpi tea or Clitoria ternatea flower extract (CTE) on changes in serum protein carbonyls and urine 5-Hydroxyindoleacetic acid (5-HIAA) levels in those experiencing diabetic distress.

Materials and methods: A comparative study conducted with 30 healthy voluntaries as control group- CON, 90 type-2 diabetic patients experiencing moderate distress (as determined by a DDS-17 score between 2 and 3), 30 patients were assigned to either the DIAB, CTE-1 or CTE-2, with the CTE-1 group receiving 5 daily for 12 weeks and the CTE-2 group receiving 10 daily. Serum protein carbonyls and urinary 5-HIAA levels were assessed at the end of the twelfth week to conclude the preventive role of CTE on diabetic distress in the type-2 diabetic population.

Results: Out of the 114 individuals initially enrolled in the study, 90 were included in the final analysis. The diabetic distress group (DIAB) exhibited significantly elevated levels of protein carbonyls and significantly decreased levels of 5-HIAA (p<0.001). In comparison to the CON group, the administration of both Shankhpushpi 5 g and 10 g extracts resulted in a significant reduction in serum protein carbonyls and an increase in urinary 5-HIAA, demonstrating a statistically significant compared with control (p<0.001).

Conclusion: Shankhpushpi tea supplementation is beneficial in improvement of diabetic distress (quality of life) in diabetic patients.

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阴蒂茶治疗2型糖尿病患者糖尿病窘迫的临床研究。

目的：本研究的目的是评估补充山普皮茶或阴蒂花提取物（CTE）对糖尿病患者血清蛋白羰基和尿5-羟基吲哚乙酸（5-HIAA）水平的影响。材料和方法：一项比较研究，30名健康志愿者作为对照组- CON， 90名患有中度痛苦的2型糖尿病患者（由DDS-17评分在2到3之间确定），30名患者被分配到DIAB， CTE-1或CTE-2， CTE-1组每天接受5次，持续12周，CTE-2组每天接受10次。在第12周结束时评估血清蛋白羰基和尿5-HIAA水平，以总结CTE对2型糖尿病人群糖尿病困扰的预防作用。结果：在最初参与研究的114个人中，有90人被纳入最终分析。糖尿病窘迫组（DIAB）蛋白羰基水平显著升高，5-HIAA水平显著降低(p)。结论：山普匹茶可改善糖尿病窘迫（生活质量）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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