[Antibiotic pharmacokinetics in rats with an infected inflammation].

Abstract

Penetration of antibiotics into infected inflammation foci depended on the level of their binding to serum proteins. Low binding ampicillin provided the highest levels of the free antibiotic in both serum and the inflammation foci. At the same time coefficients of antibiotic penetration into purulent infiltrates and infected tissues were close and amounted approximately to 70-80 per cent. Antibiotic elimination from the infection foci was retarded as compared to that from serum.