Introducing ICAM1 as a possible drug target in treatment of eosinophilic esophagitis.

Abstract

Aim: Determining of more details of Eosinophilic esophagitis (EoE) molecular mechanism is the main aim of this study.

Background: EoE is a chronic inflammatory disease associated with eosinophilic infiltration of the squamous epithelium and malfunction of immune system. Roles of number interleukins such as IL4, IL5, and IL13 are highlighted as the dysregulated genes innEoE.

Methods: The significant differentially expressed genes (DEGs) of patient sample versus health controls are explored from Gene Expression Omnibus database and evaluated via GEO2R and directed protein-protein interaction (PPI) analyses to find the key genes that promote EoE. Gene ontology enrichment was applied to screen the critical genes.

Results: IL1B, ICAM1, MAPK3, RAC2, IFNG, HGF, FGF2, IRS1, CCL2, GRAP, GNAO1, TBX21, IGF1, SPI1, BMP4, FLT4, MMP2, and PDGFRB were pointed out as the critical genes associated with EoE disease. Significant roles of IL1B and FGF2 were considered as important molecular event in EoE promotion. ICAM1 was highlighted as a possible drug target in EoE treatment.

Conclusion: in conclusion, ICAM1 is an excellent actor in EoE disease which have controlled by the top actors as IL1B and FGF2. However, it has controlled by IFNG. Regulation of ICAM1 is suggested as a possible therapeutic protocol to control EoE progression.