Green and safe preparation of antibacterial sutures composed of PLA ultrafine fibers

IF 3.6 4区工程技术 Q2 ENGINEERING, CHEMICAL

Polymer Engineering and Science Pub Date : 2024-09-18 DOI:10.1002/pen.26948

Yuhang Wang, H. Y. Fu, Jing Tan, Mahmoud M. Bubakir, Xiaodong Xu, Haoyi Li, Weimin Yang

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引用次数: 7

Abstract

Abstract The electrospun yarn for sutures has gained worldwide attention due to its fine fibers that resemble the extracellular matrix and its abundant functional sites. However, the use of a large number of toxic solvents poses safety risks and environmental pollution during production, making it challenging to directly apply electrospun yarn in the biomedical field. In this study, an environmentally friendly and safe method without toxic solvents was proposed for preparing antibacterial PLA ultrafine fiber sutures. This method involves melt electrospinning, hot‐stretching, low‐temperature plasma treatment, and chitosan grafting. The PLA ultrafine fiber sutures exhibit a high tensile strength which is 2.04 N before knotting and 1.57 N after knotting. The suture diameter is 118.7 μm and average fiber diameter is 1.72 μm. Chitosan grafted on the fiber surface provides excellent antibacterial properties for the sutures, with antibacterial rates against Escherichia coli and Staphylococcus aureus reaching 99.89% and 99.11%, respectively. The cell survival rate is 97.33%, while hemolysis rate is only 2.35%, demonstrating excellent biocompatibility of PLA ultrafine fiber sutures. This study presents a green and safe method for preparing clinically applicable absorbable antibacterial surgical sutures with high mechanical properties. Highlights A green and safe method for preparing PLA‐CS ultrafine fiber sutures. PLA‐CS suture with a tensile strength of 2.04 N and a fiber diameter of 1.72 μm. PLA‐CS suture with good antibacterial property and biocompatibility.

查看原文本刊更多论文

绿色安全制备聚乳酸超细纤维抗菌缝合线

电纺纱缝线因其具有类似细胞外基质的细纤维和丰富的功能位点而受到广泛关注。然而，在生产过程中大量使用有毒溶剂，存在安全隐患和环境污染，使得电纺纱直接应用于生物医学领域具有挑战性。本研究提出了一种环保、安全、无毒性溶剂的制备抗菌PLA超细纤维缝合线的方法。该方法包括熔体静电纺丝、热拉伸、低温等离子体处理和壳聚糖接枝。PLA超细纤维缝合线具有较高的抗拉强度，打结前为2.04 N，打结后为1.57 N。缝线直径为118.7 μm，光纤平均直径为1.72 μm。在纤维表面接枝壳聚糖，对大肠杆菌和金黄色葡萄球菌的抑菌率分别达到99.89%和99.11%。细胞存活率为97.33%，溶血率仅为2.35%，表明PLA超细纤维缝合线具有良好的生物相容性。本研究提出了一种绿色安全的制备临床适用的高机械性能可吸收抗菌手术缝合线的方法。一种绿色安全的制备PLA - CS超细纤维缝合线的方法。PLA - CS缝线的抗拉强度为2.04 N，纤维直径为1.72 μm。PLA - CS缝线具有良好的抗菌性能和生物相容性。

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来源期刊

Polymer Engineering and Science 工程技术-高分子科学

CiteScore

5.40

自引率

18.80%

发文量

329

审稿时长

3.7 months

期刊介绍： For more than 30 years, Polymer Engineering & Science has been one of the most highly regarded journals in the field, serving as a forum for authors of treatises on the cutting edge of polymer science and technology. The importance of PE&S is underscored by the frequent rate at which its articles are cited, especially by other publications - literally thousand of times a year. Engineers, researchers, technicians, and academicians worldwide are looking to PE&S for the valuable information they need. There are special issues compiled by distinguished guest editors. These contain proceedings of symposia on such diverse topics as polyblends, mechanics of plastics and polymer welding.