RTKN2, a potential target of breast cancer (BCa), can promote the growth and migration of breast cancer cells

IF 0.5 4区医学 Q4 OBSTETRICS & GYNECOLOGY

European journal of gynaecological oncology Pub Date : 2023-01-01 DOI:10.22514/ejgo.2023.108

Yantao Cai, Wanting Bao, Beili Zhang, A Lucarelli, M Martins, J Guedes, G Huang, M Liang, H Liu, J Huang, P Li, C Wang, X Pang, R Li, D Shi, X Pan, C Ma, G Zhang, J Liao, G Dong, W Zhu, B Wulaer, H Mizoguchi, M Sawahata, S Ubeysinghe, D Kankanamge, W Thotamune, D Wijayaratna, T Mohan, A Karunarathne, Y Liao, J Zeng, J Zhou, G Yang, K Ding, X Zhang, X Wang, L Zhang, Wang Wang, Y Chen, Y Xie, R, H Zhao, J Yin, X Chen, J Wu, W Wang, L Tang, Z Lin, D Li, W Cheng, J Wu, K Wang, Y Hu, W Wei, H Chen, S Liu, F Derakhshan, J Reis-Filho, Y Jiang, D Ma, C Suo, J Shi, M Xue, X Hu, Q Guo, D Li, X Luo, Y Yuan, T Li, H Liu, B Peng, J Ortega, L Gu, Z Chang, G Li, R Nusse, H Clevers, M Nalli, D Masci, A Urbani, La Regina, G Silvestri, R, S Shang, F Hua, Z Hu, Y Li, Jin Van Pelt, G Van Dam, H Yu, X Mesker, W

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引用次数: 0

Abstract

Breast cancer (BCa) is a type of malignancy; however, the exact mechanisms responsible for breast cancer have yet to be elucidated. Rhotekin 2 (RTKN2) is a member of the Rhotekin family. Previous studies demonstrated that RTKN2 is highly expressed in numerous tumors. Previous analysis of the The cancer genome altas (TCGA) database demonstrated that PRKN2 was overexpressed in BCa. However, RTKN2 is rarely reported in BCa and the mechanisms remain unclear. The aim of this study was to elucidate the effect of RTKN2 on the growth of breast cancer cells and investigate the mechanisms involved. Our analysis revealed high expression of RTKN2 in human BCa. The depletion of RTKN2 suppressed the growth of breast cancer cells. In addition, the knockout of RTKN2 restrained the progression of BCa. We also revealed that the knockdown of RTKN2 stimulated cell cycle arrest in BCa. Mechanistically, RTKN2 mediated the Wnt/β-catenin axis to affect the progression of breast cancer. In conclusion, RTKN2 promotes the growth and migration of breast cancer cells by mediating the Wnt/β-catenin axis.

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RTKN2是乳腺癌的潜在靶点（BCa），可以促进乳腺癌细胞的生长和迁移

乳腺癌（BCa）是一种恶性肿瘤；然而，导致乳腺癌的确切机制尚未阐明。Rhotekin 2 （RTKN2）是Rhotekin家族的一员。先前的研究表明，RTKN2在许多肿瘤中高表达。先前对the cancer genome altas （TCGA）数据库的分析表明，PRKN2在BCa中过表达。然而，RTKN2在BCa中很少报道，其机制尚不清楚。本研究旨在阐明RTKN2对乳腺癌细胞生长的影响并探讨其机制。我们的分析显示RTKN2在人BCa中高表达。RTKN2的缺失抑制了乳腺癌细胞的生长。此外，敲除RTKN2抑制了BCa的进展。我们还发现RTKN2的敲低刺激BCa细胞周期阻滞。机制上，RTKN2介导Wnt/β-catenin轴影响乳腺癌的进展。综上所述，RTKN2通过介导Wnt/β-catenin轴促进乳腺癌细胞的生长和迁移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of gynaecological oncology 医学-妇产科学

自引率

25.00%

发文量

审稿时长

1 months

期刊介绍： EJGO is dedicated to publishing editorial articles in the Distinguished Expert Series and original research papers, case reports, letters to the Editor, book reviews, and newsletters. The Journal was founded in 1980 the second gynaecologic oncology hyperspecialization Journal in the world. Its aim is the diffusion of scientific, clinical and practical progress, and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists, and so on.