Prognostic Implications of Chemokine Signaling Pathway Mutations for Immune Checkpoint Inhibitor Therapy in Colon Adenocarcinoma

Abstract

In recent years, immunotherapy has gained prominence both as a therapeutic option and as a major topic of cancer research. Despite this progress, the effectiveness of immune checkpoint inhibitors (ICI) in colorectal cancer remains limited, largely because current biomarkers can identify only a small fraction of patients who will benefit. Since chemokine signaling plays a key role in guiding immune cell recruitment and shaping antitumor immunity, this study examined whether alterations in chemoki