A novel nanomaterial baffle decrease aerosols and microbial aerosols during non-contact tonometry measurements

Q4 Medicine

Russian Journal of Clinical Ophthalmology Pub Date : 2024-01-01 DOI:10.32364/2311-7729-2024-24-4-9

Xiaojing Shen, Yu Guo, Xianfeng Wang, Ying Ye, Qijin Chi, Wentao Zhou, Yangyang Xu, Pengfei Wu, Hao Zhou, Y. Chen, Chunsheng Li, Y. Chen

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Abstract

Aim: to develop a novel baffle to decrease aerosols and microbial aerosols produced during non-contact tonometry (NCT) measurements. Materials and Methods: the cluster analysis performed by Autof Analyzer software contained in MALDI-TOF MS (Autof MS 600, Autobio, China) based on microbes detected in microbial aerosols samples during NCT measurements, in human conjunctiva samples, in the air and typical strains in the database. Overall, 1594 person-time were included. The participants randomly divided into groups: NCT with a novel antimicrobial aerosol nanocomposite baffle (Group 1), NCT with a plastic baffle (Group 2), NCT without a baffle (Group 3) and participants without NCT measurements (Background investigation). NCT measurements performed in Groups 1–3.We used Air quality detectors and Air Ideal® 3P to monitor and sample aerosols and microbial aerosols during NCT measurements. Blood agar plates (Bio-kont, China) were used in the microbial sampler with a diameter of 90 mm. The plates were kept in aerobic conditions at about 25°C for 3–5 days, then the colonies on the plates were counted. Results: Staphylococcus epidermidis from microbial aerosols samples cluster with those from human samples rather than those from air. Burkholderia spp. and other microbes tested in the microbial aerosols cluster with each other rather than those in the air. Aerosols and microbial aerosols in the background did not show stable accumulation effect nor upward trend. Compared with the increasing trend of aerosols and microbial aerosols in Group 2 and Group 3, those in Group 1 were low,and showing a significant downward trend. Conclusion: Aerosolized ocular surface microorganisms (AOSM) can spread by human eyes NCT measured, pathogens may among them. The effect of plastic baffle was beneficial but volatile. Antimicrobial aerosol nano-composite baffle can effectively reduce aerosols and microbial aerosols during NCT measurements. KEYWORDS: Baffle, Bio-aerosols, Global human health, Nanocomposites, Non-contact tonometer, COVID-19, Infection surveillance and control, Glaucoma, Cornea, Sampling method. FOR CITATION: Shen X., Guo Y., Wang X., Ye Y., Chi Q., Zhou W., Xu Y., Wu P., Zhou H., Chen Y., Li C., Chen Y. A novel nanomaterial baffle decrease aerosols and microbial aerosols during non-contact tonometry measurements. Russian Journal of Clinical Ophthalmology. 2024;24(4):217–221 (in Russ.). DOI: 10.32364/2311-7729-2024-24-4-9

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一种新型纳米材料挡板在非接触式眼压测量中减少气溶胶和微生物气溶胶

目的：开发一种新型挡板，以减少非接触式血压计（NCT）测量过程中产生的气溶胶和微生物气溶胶。材料和方法：采用MALDI-TOF MS （autoof MS 600, Autobio, China）中包含的autoof Analyzer软件，对NCT测量时的微生物气溶胶样品、人结膜样品、空气中检测到的微生物和数据库中的典型菌株进行聚类分析。共纳入1594人次。参与者随机分为：使用新型抗菌气溶胶纳米复合材料挡板的NCT组（1组），使用塑料挡板的NCT组（2组），不使用挡板的NCT组（3组）和不使用NCT测量的参与者（背景调查）。在1-3组进行NCT测量。我们使用空气质量检测器和Air Ideal®3P来监测和采样NCT测量期间的气溶胶和微生物气溶胶。微生物取样器采用血琼脂平板（Bio-kont, China），直径为90 mm。在25℃左右的好氧条件下保存3-5天，然后计数板上的菌落。结果：微生物气溶胶样品中的表皮葡萄球菌与人体样品中的表皮葡萄球菌聚集在一起，而与空气样品中的表皮葡萄球菌聚集在一起。在微生物气溶胶中测试的伯克霍尔德氏菌和其他微生物彼此聚集，而不是空气中的微生物。背景气溶胶和微生物气溶胶没有稳定的累积效应，也没有上升趋势。与第2组和第3组的气溶胶和微生物气溶胶的增加趋势相比，第1组的气溶胶和微生物气溶胶的增加趋势较低，且呈显著的下降趋势。结论：雾化眼表微生物（AOSM）可通过人眼NCT检测传播，其中可能存在致病菌。塑料挡板的效果是有益的，但不稳定。抗菌气溶胶纳米复合挡板可以有效地减少NCT测量过程中的气溶胶和微生物气溶胶。关键词：遮光板、生物气溶胶、全球人类健康、纳米复合材料、非接触式眼压计、COVID-19、感染监测与控制、青光眼、角膜、采样方法引用本文：沈晓，郭勇，王晓，叶艳，迟青，周伟，徐勇，吴鹏，周慧，陈勇，李超，陈勇。一种新型纳米材料挡板在非接触测压测量中减少气溶胶和微生物气溶胶。俄罗斯临床眼科学杂志。2024；24(4): 217-221（俄文）。DOI: 10.32364 / 2311-7729-2024-24-4-9

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