A Comparative Evaluation of Colonic Microflora Profiles and Plasma Metabolites in Unilateral Ureteral Obstruction–Related Chronic Kidney Disease Following Intervention with the Chinese Medicine FuZhengHuaYuJiangZhuTongLuo versus AST-120

Abstract

Extensive research has explored how Chinese herbal formulations may slow the advancement of chronic kidney disease (CKD) by modulating colonic microflora and microbiota-derived metabolites. Despite this, it remains unclear whether FuZhengHuaYuJiangZhuTongLuo (FZHY) exerts regulatory effects on CKD that parallel those reported for AST-120.To address this question, we systematically compared the influence of FZHY and AST-120 on gut microbiota composition and plasma metabolomic profiles in a chroni