Sensor based on nickel oxide modified electrode for concurrent detection of vitamin C and paracetamol

IF 1.9 4区材料科学 Q3 CHEMISTRY, PHYSICAL

Surface Innovations Pub Date : 2025-09-08 DOI:10.1680/jsuin.25.00031

Hong Wan, Jiayan Li, Mingfang Zhan, Mohammad Jahidul Alam, Sima Akter, Huihong Liu, Sakil Mahmud

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引用次数: 2

Abstract

This study presents a nickel oxide-modified screen-printed carbon electrode (NiO/SPCE) for the simultaneous electrochemical detection of vitamin C (VC) and paracetamol (PA) in pharmaceutical formulations. NiO was electrodeposited by the potentiostatic method on the surface of SPCE atom-by-atom in a dilute solution (0.1 μM Ni2+). Physicochemical characterisations confirmed uniform NiO deposition, enhancing electron transfer kinetics and active surface area. The modified electrode exhibited distinct oxidation peaks at 0.24 and 0.48 V for VC and PA, respectively, with corresponding peak currents of 6.40 and 8.23 μA. Differential pulse voltammetry demonstrated excellent linear detection ranges of 200–893 μM for VC and 1–4.46 μM for PA, with detection limits of 15.9 and 0.254 μM, respectively. Stability and reproducibility tests yielded relative standard deviations of ≤1.31% for VC and ≤1.60% for PA over eight successive measurements. Interference studies confirmed selectivity, with negligible effects from ions and sugars at 100- and 50-fold concentrations, respectively. These findings underscore the NiO/SPCE’s potential as a robust, sensitive, platform for pharmaceutical quality control and therapeutic monitoring applications.

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基于氧化镍修饰电极的传感器同时检测维生素C和扑热息痛

本研究提出了一种氧化镍修饰的丝网印刷碳电极（NiO/SPCE），用于药物配方中维生素C （VC）和扑热息痛（PA）的同时电化学检测。在0.1 μM Ni2+的稀释溶液中，采用恒电位法在SPCE表面逐个原子沉积NiO。物理化学表征证实了均匀的NiO沉积，增强了电子传递动力学和活性表面积。修饰后的电极在VC和PA分别为0.24和0.48 V时表现出明显的氧化峰，峰值电流分别为6.40和8.23 μA。差分脉冲伏安法对VC和PA的线性检测范围分别为200 ~ 893 μM和1 ~ 4.46 μM，检出限分别为15.9 μM和0.254 μM。稳定性和重复性试验在8次连续测量中，VC的相对标准偏差≤1.31%，PA的相对标准偏差≤1.60%。干扰研究证实了选择性，离子和糖分别在100倍和50倍浓度下的影响可以忽略不计。这些发现强调了NiO/SPCE作为一个强大、灵敏的药物质量控制和治疗监测应用平台的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surface Innovations CHEMISTRY, PHYSICALMATERIALS SCIENCE, COAT-MATERIALS SCIENCE, COATINGS & FILMS

CiteScore

5.80

自引率

22.90%

发文量

期刊介绍： The material innovations on surfaces, combined with understanding and manipulation of physics and chemistry of functional surfaces and coatings, have exploded in the past decade at an incredibly rapid pace. Superhydrophobicity, superhydrophlicity, self-cleaning, self-healing, anti-fouling, anti-bacterial, etc., have become important fundamental topics of surface science research community driven by curiosity of physics, chemistry, and biology of interaction phenomenon at surfaces and their enormous potential in practical applications. Materials having controlled-functionality surfaces and coatings are important to the manufacturing of new products for environmental control, liquid manipulation, nanotechnological advances, biomedical engineering, pharmacy, biotechnology, and many others, and are part of the most promising technological innovations of the twenty-first century.