Gut microbiota responses to bariatric surgery are associated with metabolic outcomes and type 2 diabetes remission.

IF 20.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2026-05-07 DOI:10.1038/s42255-026-01525-9

Lisa M Olsson, Heidi Borgeraas, Rima M Chakaroun, Dag Hofsø, Jens Kristoffer Hertel, Chinmay Dwibedi, Matthias Mitteregger, Jens Juul Holst, Valentina Tremaroli, Jøran Hjelmesæth, Fredrik Bäckhed

{"title":"Gut microbiota responses to bariatric surgery are associated with metabolic outcomes and type 2 diabetes remission.","authors":"Lisa M Olsson, Heidi Borgeraas, Rima M Chakaroun, Dag Hofsø, Jens Kristoffer Hertel, Chinmay Dwibedi, Matthias Mitteregger, Jens Juul Holst, Valentina Tremaroli, Jøran Hjelmesæth, Fredrik Bäckhed","doi":"10.1038/s42255-026-01525-9","DOIUrl":null,"url":null,"abstract":"<p><p>Bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), improve obesity and type 2 diabetes (T2D). Both surgeries affect the gut microbiota, but their contribution to T2D remission remains unclear. In this subanalysis (RYGB, n = 39; SG, n = 38) of the randomized controlled Oseberg trial ( NCT01778738 ), in which participants underwent either RYGB or SG surgery, we profiled the faecal microbiome of individuals with obesity and T2D before and 12 months after surgery. We show that both surgeries altered the microbiome in the same direction, but with larger changes after RYGB. The SG-associated altered microbiome composition correlated positively with circulating glucagon-like peptide 1 levels, beta-cell function and 5 year T2D remission. Remission was also linked to increased gene richness and metabolic potential for fermentation, methanogenesis and butyrate production. Notably, these associations persisted after accounting for the extent of weight loss. Our findings indicate that surgery-specific microbial adaptations influence metabolic improvements and may help to explain heterogeneity in T2D remission after bariatric surgery.</p>","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":" ","pages":""},"PeriodicalIF":20.8000,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s42255-026-01525-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), improve obesity and type 2 diabetes (T2D). Both surgeries affect the gut microbiota, but their contribution to T2D remission remains unclear. In this subanalysis (RYGB, n = 39; SG, n = 38) of the randomized controlled Oseberg trial ( NCT01778738 ), in which participants underwent either RYGB or SG surgery, we profiled the faecal microbiome of individuals with obesity and T2D before and 12 months after surgery. We show that both surgeries altered the microbiome in the same direction, but with larger changes after RYGB. The SG-associated altered microbiome composition correlated positively with circulating glucagon-like peptide 1 levels, beta-cell function and 5 year T2D remission. Remission was also linked to increased gene richness and metabolic potential for fermentation, methanogenesis and butyrate production. Notably, these associations persisted after accounting for the extent of weight loss. Our findings indicate that surgery-specific microbial adaptations influence metabolic improvements and may help to explain heterogeneity in T2D remission after bariatric surgery.

查看原文本刊更多论文

肠道菌群对减肥手术的反应与代谢结果和2型糖尿病缓解有关。

减肥手术，如Roux-en-Y胃旁路手术（RYGB）和袖式胃切除术（SG），可以改善肥胖和2型糖尿病（T2D）。这两种手术都会影响肠道菌群，但它们对T2D缓解的作用尚不清楚。在随机对照Oseberg试验（NCT01778738）的亚分析（RYGB, n = 39； SG, n = 38）中，参与者接受RYGB或SG手术，我们分析了肥胖和T2D患者术前和术后12个月的粪便微生物组。我们发现，这两种手术在相同的方向上改变了微生物群，但RYGB手术后的变化更大。sg相关的微生物组组成改变与循环胰高血糖素样肽1水平、β细胞功能和5年T2D缓解呈正相关。缓解也与增加的基因丰富度和发酵、产甲烷和丁酸盐生产的代谢潜力有关。值得注意的是，在考虑到体重减轻的程度后，这些关联仍然存在。我们的研究结果表明，手术特异性微生物适应影响代谢改善，并可能有助于解释减肥手术后T2D缓解的异质性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.