IL-32 as a potential biomarker and therapeutic target in cardiovascular disease.

IF 5.9 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2026-04-22 eCollection Date: 2026-01-01 DOI:10.3389/fimmu.2026.1755759

Lingyue Qiu, Jing Ye, Ling Liu, Qingwei Ji

引用次数: 0

Abstract

Cardiovascular diseases remain a leading cause of death worldwide, driven by complex pathological mechanisms involving various cytokines and inflammatory responses. IL-32, a recently discovered cytokine, has emerged as a key player in the pathogenesis of cardiovascular diseases, including atherosclerosis, myocardial infarction, and heart failure. This review summarizes the biological characteristics of IL-32 and its role in cardiovascular diseases, explores its involvement in inflammatory responses and other pathological processes, and evaluates its potential as both a biomarker and a therapeutic target. Collectively, this review aims to provide new insights for the prevention and treatment of cardiovascular diseases.

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IL-32作为潜在的生物标志物和心血管疾病治疗靶点。

心血管疾病仍然是世界范围内死亡的主要原因，由涉及各种细胞因子和炎症反应的复杂病理机制驱动。IL-32是最近发现的一种细胞因子，在动脉粥样硬化、心肌梗死和心力衰竭等心血管疾病的发病机制中起着关键作用。本文综述了IL-32的生物学特性及其在心血管疾病中的作用，探讨了其在炎症反应和其他病理过程中的作用，并评估了其作为生物标志物和治疗靶点的潜力。综上所述，本文旨在为心血管疾病的预防和治疗提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.