Association Between Bilirubin and Klotho Levels in US Middleaged and Older Adults: NHANES 2007-2016.

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current molecular medicine Pub Date : 2026-04-24 DOI:10.2174/0115665240425215251212075747

Cunbao Ling, Libing Tian, Jielei Sun, Yuxin Yin, Xiumei Cheng

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引用次数: 0

Abstract

Objective and methods: Bilirubin, a potent endogenous antioxidant, protects against multiple diseases. This cross-sectional study explored the relationship between Serum Total Bilirubin (STB) and Serum Klotho (S-Klotho, an anti-aging biomarker) in 40-79-year-olds from the 2007-2016 NHANES survey. Statistical analysis used a multivariable regression model; a Restricted Cubic Spline (RCS) model evaluated potential non-linear STB-S-Klotho associations. Subgroup analyses and sensitivity tests ensured the robustness.

Results: The analysis included 4,562 individuals aged 40-79. Both unadjusted and adjusted models showed a significant positive association between STB and S-Klotho (β = 2.84, P = 0.02 in the weighted, fully adjusted model). The RCS curve indicated no significant non-linearity (P for non-linearity = 0.211). Subgroup analyses revealed stronger associations in females, normal-weight individuals, and those without diabetes mellitus (DM) or hypertension.

Discussion: This is the first study exploring the STB-S-Klotho relationship. While human studies on bilirubin's role in aging have inconsistent conclusions, animal and mechanistic research show that elevated bilirubin reduces oxidative stress and inflammation, potentially protecting against age-related conditions.

Conclusion: Our findings confirm a positive STB-S-Klotho correlation in middle-aged and older adults, suggesting bilirubin may be a potential S-Klotho biomarker and reflect biological aging processes.

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美国中老年人胆红素和Klotho水平的关系：NHANES 2007-2016。

目的与方法：胆红素是一种有效的内源性抗氧化剂，具有预防多种疾病的作用。这项横断面研究探讨了2007-2016年NHANES调查中40-79岁人群的血清总胆红素（STB）和血清Klotho （S-Klotho，一种抗衰老生物标志物）之间的关系。统计分析采用多变量回归模型；限制三次样条（RCS）模型评估了潜在的非线性STB-S-Klotho关联。亚组分析和敏感性测试确保了稳健性。结果：分析包括4,562名年龄在40-79岁之间的人。未调整模型和调整模型均显示STB与S-Klotho呈显著正相关（β = 2.84，加权完全调整模型P = 0.02）。RCS曲线无显著非线性（非线性P = 0.211）。亚组分析显示，在女性、正常体重个体和没有糖尿病或高血压的人群中，这种相关性更强。讨论：这是首次探讨STB-S-Klotho关系的研究。虽然关于胆红素在衰老过程中的作用的人体研究得出了不一致的结论，但动物和机制研究表明，胆红素升高可以减少氧化应激和炎症，可能预防与年龄有关的疾病。结论：我们的研究结果证实了STB-S-Klotho与中老年人群呈正相关，提示胆红素可能是一种潜在的S-Klotho生物标志物，反映了生物衰老过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.