Impact of controlled type 2 diabetes on muscle-tendon mechanics.

IF 2.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2026-05-06 DOI:10.1007/s00592-026-02705-5

Riccardo Magris, Andrea Monte, Nicolò Vigolo, Francesca Nardello, Michele Trinchi, Carlo Negri, Paolo Gisondi, Chiara Cosma, Giovanni Sartore, Annunziata Lapolla, Paolo Moghetti, Paola Zamparo

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引用次数: 0

Abstract

Aims: This study aimed to investigate the impact of type 2 diabetes (T2D) on muscle and tendon mechanics by comparing individuals with controlled diabetes to a healthy cohort matched for age, BMI, and physical activity level. A secondary aim was to investigate the possible association between muscle-tendon proprieties and glycated haemoglobin (HbA1c) or advanced glycated end products (AGE, RAGE) as determined in blood and skin biopsies.

Methods: Twenty-eight patients and eighteen controls were recruited for this study. Achilles tendon stiffness (k_T), muscle-tendon stiffness (k_M, in gastrocnemius medialis) and the rate of torque development (RTD) were evaluated by combining dynamometric and ultrasound data.

Results: Diabetic patients showed increased tendon stiffness and reduced tendon elongation compared to controls, but similar RTD and k_M values. No differences in advanced glycation end products (in serum or biopsies) were observed between cohorts, but a significant positive correlation was observed between k_T and HbA1c (r = 0.610, N = 46, P < 0.001).

Conclusion: Our data indicate that muscle, but not tendon, properties can be preserved in controlled and physically active diabetic patients and that higher tendon stiffness does not result in a functional deficit (i.e., same explosive capacity between cohorts). Although this study is cross-sectional and has a limited sample size, our data suggest a potential role of HbA1c as a non-invasive biomarker of altered tendon mechanics in people with diabetes.

Clinicaltrials:

Gov, protocol number: NCT05585502.

查看原文本刊更多论文

控制2型糖尿病对肌肉肌腱力学的影响。

目的：本研究旨在通过将控制糖尿病的个体与年龄、BMI和体力活动水平相匹配的健康队列进行比较，探讨2型糖尿病（T2D）对肌肉和肌腱力学的影响。第二个目的是研究肌肉肌腱特性与血液和皮肤活检中确定的糖化血红蛋白（HbA1c）或晚期糖化终产物（AGE， RAGE）之间的可能关联。方法：选取28例患者和18例对照组。结合动力测量和超声数据评估跟腱刚度（kT）、腓肠肌内侧肌-肌腱刚度（kM）和扭矩发展率（RTD）。结果：与对照组相比，糖尿病患者的肌腱刚度增加，肌腱伸长减少，但RTD和kM值相似。晚期糖基化终产物（血清或活检）在队列之间没有差异，但kT和HbA1c之间存在显著的正相关（r = 0.610, N = 46， P）。结论：我们的数据表明，在控制和体力活动的糖尿病患者中，肌肉而不是肌腱的特性可以保留，较高的肌腱硬度不会导致功能缺陷（即队列之间的爆发能力相同）。虽然这项研究是横断面的，样本量有限，但我们的数据表明，HbA1c作为糖尿病患者肌腱力学改变的非侵入性生物标志物的潜在作用。临床试验：Gov，方案号：NCT05585502。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.