Functionality-Matched Semicarbazone Reagents Allow Access to X-ray Quality Crystals and Solids of Diverse Organic Molecules.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2027-05-06 DOI:10.1021/acs.orglett.6c01328

Emily R Sherman, Jeffrey S Johnson

引用次数: 0

Abstract

A flexible approach to crystalline compounds was developed: lipophilic structures of interest were connected to pro-crystalline semicarbazone reagents via copper-catalyzed azide-alkyne cycloaddition or Brønsted-Lowry acid-base reactions. A variety of lipophilic structures, including esters, carbamates, acids and amines were converted into crystalline solids as determined by powder X-ray diffraction (mp 134 to >240 °C). Single crystal X-ray diffraction revealed hydrogen-bond interactions between the semicarbazone and charged ammonium or acetate groups that may aid in ordering the crystals.

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功能匹配的氨基脲试剂允许访问不同有机分子的x射线质量晶体和固体。

开发了一种灵活的结晶化合物方法：通过铜催化叠氮化物-炔环加成或Brønsted-Lowry酸碱反应，将感兴趣的亲脂结构与原晶氨基脲试剂连接。通过粉末x射线衍射（mp 134 ~ >240℃）测定，各种亲脂结构，包括酯类、氨基甲酸酯类、酸类和胺类转化为结晶固体。单晶x射线衍射显示缩氨基脲与带电荷的铵基或乙酸基之间存在氢键相互作用，这可能有助于排列晶体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.