Phosphate Kinetic Modeling in Patients Treated With Hemodialysis or Hemodiafiltration: A Prospective, Multicenter, Cross-Sectional Study.

IF 1 4区医学 Q3 UROLOGY & NEPHROLOGY

Seminars in Dialysis Pub Date : 2026-04-30 DOI:10.1111/sdi.70029

Hegbrant Jörgen, Bernat Amparo, Simorra Rita, Del Castillo Domingo, Pizarro Jose Luis, Jarava Carlos, Caparros Sonia, Strippoli Giovanni F M, Daugirdas John T

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引用次数: 0

Abstract

Background: Studies suggest increased phosphate removal when using hemodiafiltration (HDF) compared with hemodialysis (HD), but a complete analytic comparison has not been reported.

Methods: We analyzed data from a 6-month prospective, multicenter, cross-sectional study that enrolled patients treated with high-flux HD or HDF and in whom residual kidney phosphate clearances (KrPhos) were measured. Modeling data and dietary survey data were available from 115 patients (59 treated with HD and 56 treated with HDF).

Results: Predialysis (midweek) serum phosphate values averaged 4.37 ± 1.00 and 4.60 ± 1.18 mg/dL in the HD and HDF groups (p = NS). Mean prescribed phosphate binder equivalent dose (PBED) (including zero values) was 3.33 ± 2.94 g/day in HD and 2.64 ± 2.68 g/day in HDF (p = 0.19). Mean modeled phosphate ingestion was similar in HD and HDF (911 ± 231 vs. 911 ± 300 mg/day, p = NS), but phosphate ingestion by dietary survey was higher in HDF vs. HD (1119 ± 520 vs. 801 ± 420 mg/day, p < 0.001). Mean predialysis serum phosphate values in patients with residual kidney function (defined as KrPhosWater > 1.0 mL/min) and anuric patients were similar (4.43 ± 0.73 vs. 4.50 ± 1.20 mg/dL, respectively), whereas mean prescribed PBED was lower in patients with KrPhosWater > 1.0 mL/min (1.83 ± 2.02 vs. 3.40 ± 2.96 g/day, p < 0.01).

Conclusions: Predialysis serum phosphate is not always lower in patients treated with HDF compared with HD, and this can possibly be explained by a trend to a lower prescribed PBED and/or by a higher dietary phosphate intake.

查看原文本刊更多论文

血液透析或血液滤过治疗患者的磷酸盐动力学模型：一项前瞻性、多中心、横断面研究。

背景：研究表明，与血液透析（HD）相比，使用血液滤过（HDF）可以增加磷酸盐的去除，但尚未有完整的分析比较报道。方法：我们分析了一项为期6个月的前瞻性、多中心、横断面研究的数据，该研究纳入了接受高通量HD或HDF治疗的患者，并测量了残留肾磷酸盐清除率（KrPhos）。建模数据和饮食调查数据来自115例患者（59例HD治疗，56例HDF治疗）。结果：透析前（周中）HD组和HDF组血清磷酸盐平均值分别为4.37±1.00和4.60±1.18 mg/dL （p = NS）。HD组的平均处方磷酸盐结合剂等效剂量（PBED）（包括零值）为3.33±2.94 g/d， HDF组为2.64±2.68 g/d （p = 0.19）。意味着建模磷酸盐摄入相似在HD和HDF(911±231和911±300毫克/天,p = NS),但磷酸盐摄入膳食调查高HDF与高清(1119±520和801±420毫克/天,p 1.0 mL / min)和无尿的患者相似的(4.43±0.73和4.50±1.20 mg / dL,分别),而规定pb是降低患者KrPhosWater > 1.0毫升/分钟(1.83±2.02和3.40±2.96克/天,p结论:与HD相比，HDF治疗的患者透析前血清磷酸盐并不总是较低，这可能是由于处方PBED较低和/或膳食磷酸盐摄入量较高的趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

6.20%

发文量

审稿时长

4-8 weeks

期刊介绍： Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.