{"title":"The role of nonsense-mediated mRNA decay in aging.","authors":"Eunseok Kang, Hyunwoo C Kwon, Seung-Jae V Lee","doi":"10.1016/j.jmb.2026.169830","DOIUrl":null,"url":null,"abstract":"<p><p>Aging is a complex biological process that gradually increases vulnerability to death and susceptibility to age-related diseases. Emerging evidence indicates that nonsense-mediated mRNA decay (NMD), a conserved RNA surveillance pathway in eukaryotes, plays a crucial role in the regulation of aging and longevity. In this manuscript, we discuss the role of key NMD factors in aging at the cellular and organismal levels. We highlight the age-related decline in NMD activity in various organisms, which may increase the production of truncated proteins. In addition, we discuss how NMD contributes to longevity and the prevention of cellular senescence. Our review provides valuable information on the molecular mechanisms by which NMD regulates aging, and enhances our understanding of how mRNA quality control, especially NMD, can be utilized for contributing to healthy longevity in humans.</p>","PeriodicalId":369,"journal":{"name":"Journal of Molecular Biology","volume":" ","pages":"169830"},"PeriodicalIF":4.5000,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jmb.2026.169830","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aging is a complex biological process that gradually increases vulnerability to death and susceptibility to age-related diseases. Emerging evidence indicates that nonsense-mediated mRNA decay (NMD), a conserved RNA surveillance pathway in eukaryotes, plays a crucial role in the regulation of aging and longevity. In this manuscript, we discuss the role of key NMD factors in aging at the cellular and organismal levels. We highlight the age-related decline in NMD activity in various organisms, which may increase the production of truncated proteins. In addition, we discuss how NMD contributes to longevity and the prevention of cellular senescence. Our review provides valuable information on the molecular mechanisms by which NMD regulates aging, and enhances our understanding of how mRNA quality control, especially NMD, can be utilized for contributing to healthy longevity in humans.
期刊介绍：
Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions.
Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.
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