{"title":"MoonProt 4.0: 2026 Update of the Moonlighting Proteins Database.","authors":"Aini Asif, Nour Farache, Wael Farache, Amman Hossain, Pranav Harish, Constance Jeffery","doi":"10.1016/j.jmb.2026.169840","DOIUrl":null,"url":null,"abstract":"<p><p>MoonProt 4.0 (http://moonlightingproteins.org) is an updated open-access database storing manually-curated annotations for moonlighting proteins. Moonlighting proteins exhibit two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here we describe an expansion in the database since our report published in 2021. With the assistance of five undergraduate annotators, we have added approximately 200 protein entries to give a total of over 700 moonlighting proteins. The new entries include more examples from plants, more transmembrane proteins and additional combinations of functions. The MoonProt Database collection of proteins with multiple functions serves as a resource for developing algorithms for predicting protein functions and provides examples of the evolution of new functions on a protein scaffold that can be valuable in developing novel methods for designing proteins with added functions.</p>","PeriodicalId":369,"journal":{"name":"Journal of Molecular Biology","volume":" ","pages":"169840"},"PeriodicalIF":4.5000,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jmb.2026.169840","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
MoonProt 4.0 (http://moonlightingproteins.org) is an updated open-access database storing manually-curated annotations for moonlighting proteins. Moonlighting proteins exhibit two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here we describe an expansion in the database since our report published in 2021. With the assistance of five undergraduate annotators, we have added approximately 200 protein entries to give a total of over 700 moonlighting proteins. The new entries include more examples from plants, more transmembrane proteins and additional combinations of functions. The MoonProt Database collection of proteins with multiple functions serves as a resource for developing algorithms for predicting protein functions and provides examples of the evolution of new functions on a protein scaffold that can be valuable in developing novel methods for designing proteins with added functions.
期刊介绍：
Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions.
Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.
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