Cannabis Use and the Risk of Incident Venous Thromboembolism Among People With HIV: A Longitudinal Cohort Study in the United States.

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The Journal of the Association of Nurses in AIDS Care : JANAC Pub Date : 2026-04-22 DOI:10.1097/JNC.0000000000000641

Lara Haidar, Robin M Nance, Stephanie A Ruderman, Andrew Hahn, Jeanne Keruly, Kristina Crothers, Mari M Kitahata, Sonia Napravnik, Richard D Moore, Geetanjali Chander, Edward Cachay, Laura Bamford, Jimmy Ma, Rob Fredericksen, Michael S Saag, Greer Burkholder, Sonya Heath, Bridget M Whitney, Lydia N Drumright, Engi F Attia, L Sarah Mixson, Peter Hunt, Joseph A C Delaney, Heidi M Crane, Sherif Eltonsy

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Abstract

Abstract: People with HIV (PWH) are at an increased risk of venous thromboembolism (VTE), and cannabis use is common in this population. However, evidence of cannabis impact on VTE risk has been conflicting and not well evaluated in PWH. Using data from five Centers for AIDS Research Network of Integrated Clinical Systems sites (2009-2020), we assessed the association between cannabis use and VTE risk. Among 13,646 PWH, 30% reported current cannabis use. In adjusted Cox models, neither former (adjusted hazard ratio [aHR] 0.78, 95% confidence interval (CI) 0.57-1.07) nor current (aHR 0.74, 95% CI 0.51-1.06) cannabis use showed a significant increase in VTE incidence compared with never use. Additionally, no dose-dependent relationship was observed between cannabis use frequency and VTE. Among PWH, cannabis use does not appear to be associated with an elevated risk of VTE. Further research is needed to elucidate the relationship between cannabis and VTE risk in this population.

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大麻使用和HIV感染者静脉血栓栓塞的风险：美国的一项纵向队列研究。

摘要：HIV感染者（PWH）发生静脉血栓栓塞（VTE）的风险增加，大麻在这一人群中很常见。然而，大麻对静脉血栓栓塞风险影响的证据是相互矛盾的，在PWH中没有得到很好的评估。使用来自五个艾滋病综合临床系统研究网络中心（2009-2020年）的数据，我们评估了大麻使用与静脉血栓栓塞风险之间的关系。在13,646名PWH中，30%报告目前使用大麻。在调整后的Cox模型中，与从未使用大麻相比，以前使用大麻（调整后的风险比[aHR] 0.78, 95%可信区间（CI） 0.57-1.07）和现在使用大麻（aHR 0.74, 95% CI 0.51-1.06）均未显示静脉血栓栓塞发生率显著增加。此外，大麻使用频率和静脉血栓栓塞之间没有剂量依赖关系。在PWH中，大麻的使用似乎与静脉血栓栓塞的风险升高无关。需要进一步的研究来阐明大麻与静脉血栓栓塞风险之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Journal of the Association of Nurses in AIDS Care : JANAC

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