{"title":"Autologous skin microfragments as a regenerative approach for chronic wound healing and burn sequelae.","authors":"H Oubari, S Serbu, M Riccio, A Mojallal","doi":"10.1016/j.anplas.2026.02.004","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic wounds represent a significant healthcare challenge, necessitating innovative regenerative approaches. Autologous skin micrografts (ASMs) offers a promising solution for impaired wound healing. The technique involves mechanical disaggregation of full-thickness skin punch biopsies into micrografts, which are then injected or combined with a biological scaffold to promote healing. This retrospective case series presents our center's experience treating chronic wounds and burn sequelae using ASMs. Twelve cases involving ten patients were analyzed, with indications ranging from chronic ulcers to post-burn scar contractures. Results showed accelerated skin healing, improved skin quality, and functional recovery. The mean time to healing was 25.2 days for wound closure and 69.6 days for scar improvement. The procedure's simplicity, minimal invasiveness, and applicability in complex cases with limited donor sites reinforce its clinical potential. ASMs may represent a viable regenerative therapy in advanced wound care.</p>","PeriodicalId":55512,"journal":{"name":"Annales De Chirurgie Plastique Esthetique","volume":" ","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales De Chirurgie Plastique Esthetique","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.anplas.2026.02.004","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Chronic wounds represent a significant healthcare challenge, necessitating innovative regenerative approaches. Autologous skin micrografts (ASMs) offers a promising solution for impaired wound healing. The technique involves mechanical disaggregation of full-thickness skin punch biopsies into micrografts, which are then injected or combined with a biological scaffold to promote healing. This retrospective case series presents our center's experience treating chronic wounds and burn sequelae using ASMs. Twelve cases involving ten patients were analyzed, with indications ranging from chronic ulcers to post-burn scar contractures. Results showed accelerated skin healing, improved skin quality, and functional recovery. The mean time to healing was 25.2 days for wound closure and 69.6 days for scar improvement. The procedure's simplicity, minimal invasiveness, and applicability in complex cases with limited donor sites reinforce its clinical potential. ASMs may represent a viable regenerative therapy in advanced wound care.
期刊介绍：
Qu''elle soit réparatrice après un traumatisme, pratiquée à la suite d''une malformation ou motivée par la gêne psychologique dans la vie du patient, la chirurgie plastique et esthétique touche toutes les parties du corps humain et concerne une large communauté de chirurgiens spécialisés.
Organe de la Société française de chirurgie plastique reconstructrice et esthétique, la revue publie 6 fois par an des éditoriaux, des mémoires originaux, des notes techniques, des faits cliniques, des actualités chirurgicales, des revues générales, des notes brèves, des lettres à la rédaction.
Sont également présentés des analyses d''articles et d''ouvrages, des comptes rendus de colloques, des informations professionnelles et un agenda des manifestations de la spécialité.
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