Keeping inflammasomes in check during bone resorption

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Science Signaling Pub Date : 2026-04-21 DOI:10.1126/scisignal.aeg1707

Caroline Schmidt, Ulf Wagner

引用次数: 0

Abstract

Ca²⁺ flux is a key trigger of NLRP3 inflammasome activation, but bone-resorbing osteoclasts operate in a Ca²⁺-rich environment created during bone resorption. In this issue of Science Signaling, Kaur et al. reveal that osteoclasts prevent inflammasome activation by limiting Ca²⁺ influx through the membrane protein Tmem178, thereby protecting bone from excessive resorption driven by inflammatory signaling.

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在骨吸收过程中控制炎症小体。

Ca2+通量是NLRP3炎性体激活的关键触发因素，但骨吸收破骨细胞在骨吸收过程中产生的富含Ca2+的环境中运作。在这一期的《科学信号》中，Kaur等人发现破骨细胞通过膜蛋白Tmem178限制Ca2+内流来防止炎性小体激活，从而保护骨骼免受炎症信号驱动的过度吸收。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Signaling BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

9.50

自引率

0.00%

发文量

148

审稿时长

3-8 weeks

期刊介绍： "Science Signaling" is a reputable, peer-reviewed journal dedicated to the exploration of cell communication mechanisms, offering a comprehensive view of the intricate processes that govern cellular regulation. This journal, published weekly online by the American Association for the Advancement of Science (AAAS), is a go-to resource for the latest research in cell signaling and its various facets. The journal's scope encompasses a broad range of topics, including the study of signaling networks, synthetic biology, systems biology, and the application of these findings in drug discovery. It also delves into the computational and modeling aspects of regulatory pathways, providing insights into how cells communicate and respond to their environment. In addition to publishing full-length articles that report on groundbreaking research, "Science Signaling" also features reviews that synthesize current knowledge in the field, focus articles that highlight specific areas of interest, and editor-written highlights that draw attention to particularly significant studies. This mix of content ensures that the journal serves as a valuable resource for both researchers and professionals looking to stay abreast of the latest advancements in cell communication science.