[The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury].

Q3 Medicine

生理学报 Pub Date : 2026-04-25 DOI:10.13294/j.aps.2025.0106

Qian Luo, Shu-Han Yang, Xia Gong

引用次数: 0

Abstract

Renal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney injury (AKI) and poor kidney transplantation outcomes. Its pathogenesis is closely related to oxidative stress, autophagy, and endoplasmic reticulum stress, although the specific mechanism is still unclear. The mammalian target of rapamycin (mTOR), as a key regulator of autophagy, plays critical roles at various stages of RIRI through different signaling pathways and contributes to mitigating renal damage. However, the underlying mechanisms require further studies. This review focuses on the role and mechanism of mTOR in RIRI and discusses the potential of mTOR as a therapeutic target.

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[自噬调节因子mTOR在肾缺血再灌注损伤中的作用及机制]。

肾缺血再灌注损伤（RIRI）是急性肾损伤（AKI）和肾移植预后不良的主要原因。其发病机制与氧化应激、自噬、内质网应激密切相关，但具体机制尚不清楚。哺乳动物雷帕霉素靶蛋白（mTOR）作为自噬的关键调节因子，通过不同的信号通路在RIRI的各个阶段发挥关键作用，有助于减轻肾损害。然而，潜在的机制需要进一步研究。本文综述了mTOR在RIRI中的作用和机制，并讨论了mTOR作为治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.