{"title":"Modern Methods of Synthesis, Chemical Properties, and Scope of Application of Betti Bases","authors":"N. N. Stepkina, A. V. Velikorodov","doi":"10.1134/S1070428025605369","DOIUrl":null,"url":null,"abstract":"<p>The review systemizes literature data on the synthesis, chemical transformations, and application of Bett bases over a period of 2004 to 2025. Various aspects of the classical Betti reaction, including conditions, catalysts, solvents, selectivity, mechanism, and compliance with the “green” chemistry principles, are considered in detail. The effects of different catalysts on the yield, reaction time, and selectivity are compared. Particular attention is given to the transformations of Betti bases, especially oxidative cyclization reactions, rearrangements, reactions with nucleophilic and electrophilic reagents, as well as reactions involving <i>o</i>-quinone methides generated therefrom. The stereochemical output of the reactions with chiral substrates is analyzed with respect to chiral auxiliary, substituent nature, catalyst, and solvent. Examples of application of Betti bases in both fundamental research (as ligands in asymmetric catalysis) and applied fields, such as medicinal chemistry and pharmacology, are given.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"62 3","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428025605369","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The review systemizes literature data on the synthesis, chemical transformations, and application of Bett bases over a period of 2004 to 2025. Various aspects of the classical Betti reaction, including conditions, catalysts, solvents, selectivity, mechanism, and compliance with the “green” chemistry principles, are considered in detail. The effects of different catalysts on the yield, reaction time, and selectivity are compared. Particular attention is given to the transformations of Betti bases, especially oxidative cyclization reactions, rearrangements, reactions with nucleophilic and electrophilic reagents, as well as reactions involving o-quinone methides generated therefrom. The stereochemical output of the reactions with chiral substrates is analyzed with respect to chiral auxiliary, substituent nature, catalyst, and solvent. Examples of application of Betti bases in both fundamental research (as ligands in asymmetric catalysis) and applied fields, such as medicinal chemistry and pharmacology, are given.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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