A Study on Electrocardiography Echocardiography and Cardiac Biomarkers in Aluminium Phosphide Poisoning and Their Prognostic Correlation.

Q3 Medicine

The Journal of the Association of Physicians of India Pub Date : 2026-04-01 DOI:10.59556/japi.74.1415

Harshvardhan Tiwari, Deepti Sharma, Meenaxi Sharda, Dinesh Bishnoi, Harshit Garg

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Abstract

Background: Aluminum phosphide (AlP) poisoning is a medical emergency with an alarmingly high mortality rate, primarily due to its rapid cardiotoxic effects.

Objective: To identify and evaluate key prognostic indicators-clinical, electrocardiographic, echocardiographic, and biochemical-in patients with AlP poisoning.

Materials and methods: A cross-sectional observational study was conducted on 100 patients with confirmed AlP ingestion. ECG changes, cardiac biomarkers (troponin-I, CPK-MB, LDH, and CPK-NAC), 2D echocardiography findings, and acid-base disturbances were analyzed in relation to survival outcomes.

Results: ECG abnormalities and decreased ejection fraction were significantly associated with mortality. Elevated cardiac biomarkers and profound acidosis were strong independent predictors of poor prognosis.

Conclusion: AlP poisoning causes critical cardiovascular compromise. Early identification of high-risk patients may guide aggressive intervention and resource allocation in intensive care settings.

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磷化铝中毒的心电图、超声心动图和心脏生物标志物及其预后相关性研究。

背景：磷化铝（AlP）中毒是一种死亡率高得惊人的医疗紧急情况，主要是由于其快速的心脏毒性作用。目的：鉴别和评价AlP中毒患者的临床、心电图、超声心动图和生化指标。材料与方法：对100例确诊AlP摄入的患者进行横断面观察研究。分析心电图变化、心脏生物标志物（肌钙蛋白- i、CPK-MB、LDH和CPK-NAC）、二维超声心动图结果和酸碱干扰与生存结果的关系。结果：心电图异常和射血分数降低与死亡率显著相关。心脏生物标志物升高和深度酸中毒是预后不良的独立预测因素。结论：AlP中毒可引起严重的心血管损害。高危患者的早期识别可以指导重症监护机构的积极干预和资源分配。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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