Effects of Delivery with Epidural Anesthesia on Peripartum Serum Inflammatory Factors and Hemodynamics in Women with Gestational Hypertension.

IF 2.7 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Gynecologic and Obstetric Investigation Pub Date : 2026-01-01 Epub Date: 2026-04-18 DOI:10.1159/000551804

Fei Chen, Wen-Kai Li, Li-Li Yin, Yun-Xia Chen, Rui-Qian Lai, Dong-Ya Zhang, Yan-Peng Hao

{"title":"Effects of Delivery with Epidural Anesthesia on Peripartum Serum Inflammatory Factors and Hemodynamics in Women with Gestational Hypertension.","authors":"Fei Chen, Wen-Kai Li, Li-Li Yin, Yun-Xia Chen, Rui-Qian Lai, Dong-Ya Zhang, Yan-Peng Hao","doi":"10.1159/000551804","DOIUrl":null,"url":null,"abstract":"Objective: The aim of the study was to analyze the changes in serum inflammatory factors and hemodynamics in women with hypertensive disorder of pregnancy (HDCP) who undergo delivery with epidural anesthesia.Methods: A total of 100 HDCP pregnant women were admitted to our hospital from June 2021 to December 2023 and divided into a control group (conventional delivery, i.e., vaginal delivery without analgesia) and a painless group (delivery with epidural anesthesia, i.e., continuous epidural analgesia), with 50 cases in each group. The levels of serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as hemodynamic parameters including heart rate (HR), mean arterial pressure (MAP), and cardiac output (CO), were measured and compared between the two groups at the following time points: pre-analgesia (T1), full cervical dilation (T2), fetal delivery (T3), and 24-h postpartum (T4). Maternal and neonatal outcomes were also compared between the two groups.Results: The painless group had shorter first, second, and third stages of labor and colostrum time than the control group, and the 1-min APGAR score was higher than that of the control group (p < 0.05). The TNF-α and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (p < 0.05). The TNF-α and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (p < 0.05). The fluctuation range of MAP, HR, and CO levels in T2, T3, and T4 in the painless group was smaller than that in the control group (p < 0.05).Conclusion: Delivery with epidural anesthesia for HDCP mothers can reduce perinatal inflammatory factor levels and stabilize hemodynamic parameters.","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"563-572"},"PeriodicalIF":2.7000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gynecologic and Obstetric Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000551804","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/4/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The aim of the study was to analyze the changes in serum inflammatory factors and hemodynamics in women with hypertensive disorder of pregnancy (HDCP) who undergo delivery with epidural anesthesia.

Methods: A total of 100 HDCP pregnant women were admitted to our hospital from June 2021 to December 2023 and divided into a control group (conventional delivery, i.e., vaginal delivery without analgesia) and a painless group (delivery with epidural anesthesia, i.e., continuous epidural analgesia), with 50 cases in each group. The levels of serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as hemodynamic parameters including heart rate (HR), mean arterial pressure (MAP), and cardiac output (CO), were measured and compared between the two groups at the following time points: pre-analgesia (T1), full cervical dilation (T2), fetal delivery (T3), and 24-h postpartum (T4). Maternal and neonatal outcomes were also compared between the two groups.

Results: The painless group had shorter first, second, and third stages of labor and colostrum time than the control group, and the 1-min APGAR score was higher than that of the control group (p < 0.05). The TNF-α and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (p < 0.05). The TNF-α and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (p < 0.05). The fluctuation range of MAP, HR, and CO levels in T2, T3, and T4 in the painless group was smaller than that in the control group (p < 0.05).

Conclusion: Delivery with epidural anesthesia for HDCP mothers can reduce perinatal inflammatory factor levels and stabilize hemodynamic parameters.

查看原文本刊更多论文

硬膜外麻醉分娩对妊娠期高血压妇女围生期血清炎症因子和血流动力学的影响。

目的：分析硬膜外麻醉分娩后妊娠期高血压病（HDCP）患者血清炎症因子及血流动力学的变化。方法：选择我院2021年6月至2023年12月收治的HDCP孕妇100例，分为对照组（常规分娩，即阴道无镇痛分娩）和无痛组（硬膜外麻醉分娩，即持续硬膜外镇痛），每组50例。比较两组患者在镇痛前（T1）、宫颈完全扩张（T2）、胎儿分娩（T3）、产后24小时（T4）时血清肿瘤坏死因子-α (TNF-α)、白细胞介素-6 （IL-6）水平及心率（HR）、平均动脉压（MAP）、心输出量（CO）等血流动力学参数。还比较了两组的产妇和新生儿结局。结果：无痛组第一、二、三产程及初乳时间均短于对照组，1 min Apgar评分高于对照组（P < 0.05）。无痛组患者T2、T3、T4组织TNF-α、IL-6水平均低于对照组（P < 0.05）。无痛组患者T2、T3、T4组织TNF-α、IL-6水平均低于对照组（P < 0.05）。无痛组T2、T3、T4 MAP、HR、CO水平波动幅度均小于对照组（P < 0.05）。结论：HDCP产妇硬膜外麻醉分娩可降低围产儿炎症因子水平，稳定血流动力学参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Gynecologic and Obstetric Investigation 医学-妇产科学

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.