From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications

IF 14.6 1区医学 Q1 PHARMACOLOGY & PHARMACY

Acta Pharmaceutica Sinica. B Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI:10.1016/j.apsb.2026.01.021

Yue Yin , Qiaoqiao Zhao , Zihan Wang , Zixuan Li , Hening Liu , Fatemeh Eghbalitabar , Jing Shang , Lu Tang , Wei Wang

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Abstract

Microneedles (MNs), as innovative biomedical devices, are undergoing a transformation from basic transdermal devices to intelligent and multifunctional systems. The advancement of intelligent MNs enhances tissue penetration and adhesion, triggers timely, on-demand and precise spatiotemporal controlled release, achieves sequential drug delivery and in situ monitoring, and enables close-loop theranostics via the integration of flexible electronics, wireless communication, and artificial intelligence. This review not only systematically highlights these cutting-edge breakthroughs, focusing on five major innovative advancements of conceptual design, including mimicking strategies, stimuli-responsive systems, innovative structural designs, living payload, and wearable integration, but also delineates the principal obstacles obstructing the advancement of intelligent MNs. We also emphasize that MN technology is fueling the evolution of next-generation medical paradigms based on its personalized, minimally invasive, and intelligent features through interdisciplinary integration, which is crucial for reshaping the future landscape of disease diagnosis and treatment.

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从概念设计到转化进展：用于生物医学应用的智能微针的新进展

微针作为一种创新的生物医学设备，正经历着从基本透皮装置向智能多功能系统的转变。智能MNs的进步增强了组织渗透和粘附，触发及时、按需和精确的时空控制释放，实现了顺序给药和原位监测，并通过柔性电子、无线通信和人工智能的集成实现了闭环治疗。本文不仅系统地介绍了这些前沿突破，重点介绍了概念设计的五大创新进展，包括模仿策略、刺激响应系统、创新结构设计、生活有效载荷和可穿戴集成，而且还描述了阻碍智能网络发展的主要障碍。我们还强调，通过跨学科的整合，MN技术正在推动下一代医学范式的发展，基于其个性化、微创和智能的特征，这对于重塑疾病诊断和治疗的未来格局至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Pharmaceutica Sinica. B Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

22.40

自引率

5.50%

发文量

1051

审稿时长

19 weeks

期刊介绍： The Journal of the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association oversees the peer review process for Acta Pharmaceutica Sinica. B (APSB). Published monthly in English, APSB is dedicated to disseminating significant original research articles, rapid communications, and high-quality reviews that highlight recent advances across various pharmaceutical sciences domains. These encompass pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis, and pharmacokinetics. A part of the Acta Pharmaceutica Sinica series, established in 1953 and indexed in prominent databases like Chemical Abstracts, Index Medicus, SciFinder Scholar, Biological Abstracts, International Pharmaceutical Abstracts, Cambridge Scientific Abstracts, and Current Bibliography on Science and Technology, APSB is sponsored by the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association. Its production and hosting are facilitated by Elsevier B.V. This collaborative effort ensures APSB's commitment to delivering valuable contributions to the pharmaceutical sciences community.