Research of the Abnormal Mechanism of Brain Functional Network in Early Mild Cognitive Impairment Patients

Abstract

At present, the brain neural mechanism of the onset of early mild cognitive impairment (EMCI) patients has not yet been clarified, and it is difficult to detect the pre-disease stage of EMCI patients and to carry out the subsequent intervention treatment. In this paper, by constructing the brain functional networks of the two subject groups of EMCI and Normal Control (NC), the mechanism of abnormalities in the brain functional networks and brain regions of the patients was investigated. Using the analysis method of complex network combined with graph theory, the global topological metrics of the brain functional networks of the subjects were investigated. Considering the compensatory mechanism of brain regions, this study starts with more fine-grained brain regions to analyse the differential characteristics of brain functional networks between patients and normal subjects. Finally, we draw the preliminary conclusion that the global structure of the brain functional network of EMCI patients has been fundamentally reorganised, and the working mechanism has been abnormally changed, and we have unearthed the abnormal brain regions that cause the global changes of the brain functional network.