Retinal ribbon synapses and the potential functional role of TIAM1: A structural and molecular perspective.

IF 1.8 3区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Vision Pub Date : 2026-02-25 eCollection Date: 2026-01-01

Martha Emil Adly

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引用次数: 0

Abstract

Purpose: Retinal and inner ear ribbon synapses are specialized sensory synapses characterized by synaptic ribbons, electron-dense and protein-rich structures that enable rapid and sustained neurotransmitter release. This review aims to examine the molecular architecture of ribbon synapses with a particular focus on the potential involvement of Tiam1, a guanine nucleotide exchange factor implicated in neuronal development and synaptic plasticity.

Methods: A comprehensive review of the available literature was conducted to summarize current knowledge on the structural organization and molecular components of ribbon synapses. Particular attention was given to studies investigating Tiam1 expression, function, and its possible role in cytoskeletal remodeling and synaptic regulation.

Results: Evidence supports the central role of RIBEYE as the primary structural component of ribbon synapses; however, the regulatory mechanisms governing ribbon formation and function remain incompletely understood. Recent studies suggest a potential contribution of Tiam1 in modulating synaptic organization and function through Rac1 activation and cytoskeletal regulation, although direct experimental evidence in ribbon synapses is still limited.

Conclusions: Ribbon synapses are critical for sustained neurotransmission in sensory systems, yet their molecular regulation remains incompletely defined. Tiam1 emerges as a promising candidate molecule that may influence ribbon synapse function. Future experimental studies are needed to clarify its localization, molecular interactions, and contribution to synaptic organization and plasticity.

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视网膜带状突触和TIAM1的潜在功能作用：一个结构和分子的观点。

目的：视网膜和内耳带状突触是一种特殊的感觉突触，其特征是突触带，电子密集和富含蛋白质的结构，能够快速和持续地释放神经递质。本综述旨在研究带状突触的分子结构，特别关注Tiam1的潜在参与，Tiam1是一种涉及神经元发育和突触可塑性的鸟嘌呤核苷酸交换因子。方法：对现有文献进行综述，总结目前对带状突触的结构组织和分子组成的认识。研究人员特别关注Tiam1的表达、功能及其在细胞骨架重塑和突触调节中的可能作用。结果：证据支持RIBEYE作为带状突触的主要结构成分的核心作用；然而，控制带形成和功能的调控机制仍然不完全清楚。最近的研究表明，Tiam1可能通过Rac1激活和细胞骨架调节来调节突触的组织和功能，尽管在带状突触中的直接实验证据仍然有限。结论：带状突触对感觉系统的持续神经传递至关重要，但其分子调控仍不完全明确。Tiam1作为一种可能影响带状突触功能的候选分子而出现。需要进一步的实验研究来阐明其定位、分子相互作用以及对突触组织和可塑性的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Vision 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Molecular Vision is a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology, and the genetics of the visual system (ocular and cortical). Molecular Vision publishes articles presenting original research that has not previously been published and comprehensive articles reviewing the current status of a particular field or topic. Submissions to Molecular Vision are subjected to rigorous peer review. Molecular Vision does NOT publish preprints. For authors, Molecular Vision provides a rapid means of communicating important results. Access to Molecular Vision is free and unrestricted, allowing the widest possible audience for your article. Digital publishing allows you to use color images freely (and without fees). Additionally, you may publish animations, sounds, or other supplementary information that clarifies or supports your article. Each of the authors of an article may also list an electronic mail address (which will be updated upon request) to give interested readers easy access to authors.