Trans-cytolemmal water exchange in prostate manifest via DCE-MRI.

IF 2.5 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-04-15 DOI:10.1007/s10334-026-01345-8

Xin Li, Ryan P Kopp, William D Rooney, Charles S Springer, Fergus V Coakley, Mark G Garzotto

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引用次数: 0

Abstract

Objective: To investigate the potential of the unidirectional cellular water efflux rate constant (k_io) from DCE-MRI data in prostate MR imaging.

Materials and methods: High-temporal-resolution prostate DCE-MRI data were modeled using both the fast-exchange-limit (FXL) Tofts' model as well as the water-exchange-sensitized shutter-speed model (SSM). In the SSM, k_io was included as an additional fitting parameter. Lesion and normal-appearing (NA) prostate tissue region-of-interest (ROI) data were analyzed and categorized into FXL or non-FXL conditions based on results from the two models. A global upper limit of k_io detectable by prostate DCE-MRI with the SSM was presented.

Results: While many lesion voxels exhibited sensitivity to k_io with the SSM, a substantial portion remained in the FXL condition despite greater contrast agent extravasation than in NA tissue. The fraction of FXL voxels was higher in lesions than in NA tissue. Applying a global detectable k_io upper limit increased the difference between lesion and NA ROIs, improving lesion characterization.

Discussion: SSM-derived FXL and non-FXL contrasts may serve as novel imaging biomarkers for prostate cancer surveillance. Advances in MRI technology and more potent contrast agents are expected to enhance the accuracy of k_io quantification, potentially enabling its integration into clinical mpMRI.

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DCE-MRI显示前列腺跨细胞质水交换。

目的：探讨DCE-MRI数据在前列腺磁共振成像中的单向水流出率常数（kio）的潜力。材料和方法：使用快速交换极限（FXL） Tofts模型和水交换敏化快门速度模型（SSM）对高时间分辨率前列腺DCE-MRI数据进行建模。在SSM中，kio被作为一个附加的拟合参数。根据两种模型的结果，分析病变和正常显示（NA）前列腺组织感兴趣区域（ROI）数据，并将其分为FXL或非FXL。提出了前列腺DCE-MRI与SSM检测kio的整体上限。结果：虽然许多病变体素在SSM中表现出对kio的敏感性，但FXL条件下仍有相当一部分存在，尽管造影剂外渗比NA组织大。FXL体素在病变组织中的比例高于NA组织。应用全局可检测的kio上限增加了病变和NA roi之间的差异，改善了病变特征。讨论：ssm衍生的FXL和非FXL对比可能作为前列腺癌监测的新型成像生物标志物。MRI技术的进步和更有效的造影剂有望提高kio定量的准确性，有可能使其整合到临床mpMRI中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.