Subcutaneous Adipose Tissue Accumulation is Associated With an Improved Prognosis in Patients With Hepatocellular Carcinoma

IF 3.7 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Research Pub Date : 2026-08-03 Epub Date: 2026-04-15 DOI:10.1111/hepr.70187

Kenji Imai, Koji Takai, Mikita Oi, Masashi Aiba, Shinji Unome, Takao Miwa, Hiroyasu Sakai, Yohei Shirakami, Atsushi Suetsugu, Masahito Shimizu

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Abstract

Aim

This study investigated the effects of the subcutaneous adipose tissue index (SATI) and visceral adipose tissue index (VATI) on the overall survival (OS) of patients with hepatocellular carcinoma (HCC).

Methods

This study included 587 patients with HCC. The Cox proportional hazards model was used to identify independent prognostic factors. The optimal SATI cutoff value that yielded the most significant differences in OS was determined using the maximally selected statistics. Survival was estimated using the Kaplan–Meier method, and differences between survival curves were evaluated using the log-rank test.

Results

SATI (hazard ratio, 0.99; 95% confidence interval, 0.98–0.99; p < 0.001) was significantly associated with improved OS after adjustment for potential confounders. The high-SATI group (≥ 41.1 cm²/m² for males and ≥ 48.9 cm²/m² for females) demonstrated significantly longer survival than those in the low-SATI group (p < 0.001; median survival: 87.0 vs. 40.4 months). The results of the decision tree analysis showed that patients with SATI ≥ 41.0 cm²/m² who received curative treatment demonstrated the best survival (median survival: 191.8 months). Subgroup analyses revealed that the survival advantage of the high-SATI group was consistent across most subgroups, except for patients with metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, body mass index > 25 kg/m², VATI ≥ 85 cm²/m², or hyperlipidemia.

Conclusions

In the absence of findings indicative of ectopic lipid accumulation, SAT accumulation is associated with an improved prognosis in patients with HCC.

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肝细胞癌患者皮下脂肪组织积累与预后改善相关

目的：探讨肝细胞癌（HCC）患者皮下脂肪组织指数（SATI）和内脏脂肪组织指数（VATI）对总生存期（OS）的影响。方法：本研究纳入587例HCC患者。采用Cox比例风险模型确定独立预后因素。产生OS中最显著差异的最佳SATI截止值是使用最大选择的统计数据确定的。使用Kaplan-Meier法估计生存，使用log-rank检验评估生存曲线之间的差异。结果：SATI组（风险比0.99；95%可信区间0.98-0.99；男性2/m2，女性≥48.9 cm2/m2）的生存期明显长于低SATI组(接受根治性治疗的患者生存期最佳（中位生存期：191.8个月）。亚组分析显示，高sati组的生存优势在大多数亚组中是一致的，除了代谢功能障碍相关的脂肪变性肝病、酒精相关肝病、体重指数> 25 kg/m2、VATI≥85 cm2/m2或高脂血症患者。结论：在没有发现表明异位脂质积累的情况下，SAT积累与HCC患者预后改善有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology Research 医学-胃肠肝病学

CiteScore

8.30

自引率

14.30%

发文量

124

审稿时长

1 months

期刊介绍： Hepatology Research (formerly International Hepatology Communications) is the official journal of the Japan Society of Hepatology, and publishes original articles, reviews and short comunications dealing with hepatology. Reviews or mini-reviews are especially welcomed from those areas within hepatology undergoing rapid changes. Short communications should contain concise definitive information.