Citicoline Restores Endoplasmic Reticulum Homeostasis by Regulating Oxidative Stress Through CDO1 to Reverse Myopia Progression.

IF 6.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants & redox signaling Pub Date : 2026-07-01 Epub Date: 2026-04-15 DOI:10.1177/15230864261443857

Peijuan Wu, Shan He, Li Zhang, Houli Li, Jiaxue Wu, Kun Yi, Qiuyun Sun, Ke Hu, Wenjuan Wan

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引用次数: 0

Abstract

Objective: To investigate whether citicoline alleviates endoplasmic reticulum (ER) stress by modulating oxidative stress in myopia.

Results: A form-deprivation myopia model in guinea pigs and a hypoxia-induced model in human scleral fibroblasts revealed that citicoline downregulated cysteine dioxygenase 1 (CDO1) expression, increased glutathione, and reduced reactive oxygen species. These changes mitigated oxidative stress, suppressed ER stress, maintained cellular homeostasis, and inhibited extracellular matrix remodeling, leading to reduced axial elongation.

Innovation: Transcriptomic profiling identified CDO1 as a novel downstream effector of citicoline, linking cysteine metabolism to oxidative and ER stress regulation in myopia.

Conclusion: Citicoline shows potential to delay myopia progression by alleviating ER stress through CDO1-mediated redox regulation, providing preclinical mechanistic insight into its possible role in myopia control. Antioxid. Redox Signal. 45, 113-132.

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胞糖胆碱通过CDO1调控氧化应激逆转近视进展，恢复内质网稳态。

目的：探讨胞胆碱是否通过调节近视的氧化应激来缓解内质网应激。结果：豚鼠形态剥夺性近视模型和人巩膜成纤维细胞缺氧模型显示胞胆碱下调半胱氨酸双加氧酶1 （CDO1）表达，增加谷胱甘肽，减少活性氧。这些变化减轻了氧化应激，抑制内质网应激，维持细胞稳态，抑制细胞外基质重塑，导致轴向伸长减少。创新：转录组学分析发现CDO1是胞胆碱的一种新的下游效应物，将半胱氨酸代谢与近视的氧化和内质网应激调节联系起来。结论：胞糖胆碱可能通过cdo1介导的氧化还原调节减轻内质网应激，从而延缓近视进展，为其在近视控制中的可能作用提供了临床前机制。Antioxid。氧化还原信号：00000 - 00000。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants & redox signaling 生物-内分泌学与代谢

CiteScore

14.10

自引率

1.50%

发文量

170

审稿时长

3-6 weeks

期刊介绍： Antioxidants & Redox Signaling (ARS) is the leading peer-reviewed journal dedicated to understanding the vital impact of oxygen and oxidation-reduction (redox) processes on human health and disease. The Journal explores key issues in genetic, pharmaceutical, and nutritional redox-based therapeutics. Cutting-edge research focuses on structural biology, stem cells, regenerative medicine, epigenetics, imaging, clinical outcomes, and preventive and therapeutic nutrition, among other areas. ARS has expanded to create two unique foci within one journal: ARS Discoveries and ARS Therapeutics. ARS Discoveries (24 issues) publishes the highest-caliber breakthroughs in basic and applied research. ARS Therapeutics (12 issues) is the first publication of its kind that will help enhance the entire field of redox biology by showcasing the potential of redox sciences to change health outcomes. ARS coverage includes: -ROS/RNS as messengers -Gaseous signal transducers -Hypoxia and tissue oxygenation -microRNA -Prokaryotic systems -Lessons from plant biology