Click chemistry charts covalent drug landscapes in vivo.
IF 24
1区 医学
Q1 PHARMACOLOGY & PHARMACY
Trends in pharmacological sciences
Pub Date : 2026-06-01
Epub Date: 2026-04-11
DOI:10.1016/j.tips.2026.03.005
引用次数: 0
Abstract
Covalent drugs display rich in vivo reactivity landscapes that remain largely unmapped. A recent Cell study by Pang et al. introduces vCATCH (volumetric clearing-assisted tissue click chemistry), a chemistry-driven platform combining clickable probes, bioorthogonal ligation, and whole-body imaging to chart covalent drug-target interactions across intact organisms.
点击体内共价药物的化学图。
共价药物显示出丰富的体内反应性景观，在很大程度上仍未绘制。Pang等人最近的一项细胞研究引入了vCATCH（体积清除辅助组织点击化学），这是一种化学驱动的平台，结合了可点击探针、生物正交连接和全身成像，以绘制完整生物体中共价药物-靶标相互作用的图表。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
CiteScore
23.90
自引率
0.70%
发文量
132
审稿时长
6-12 weeks
期刊介绍：
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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