{"title":"Acute Post-cataract Surgery Endophthalmitis and Corneal Ulcer with <i>Acinetobacter</i> Managed with Colistin: A Case Report.","authors":"Mohsen Pourazizi, Alireza Peyman, Alireza Dehghani, Asieh Aslani, Mahsa Pourmahdi-Boroujeni, Paria Sanei","doi":"10.4103/jrpp.jrpp_72_25","DOIUrl":null,"url":null,"abstract":"<p><p>Postoperative endophthalmitis is a rare but severe complication of phacoemulsification cataract surgery (PCS). <i>Acinetobacter baumannii</i> is an uncommon pathogen, often associated with multidrug resistance and poor outcomes. In this report, a 73-year-old male who developed endophthalmitis following PCS is introduced, who, despite intensive empirical therapy, experienced no clinical improvement. Following a vitreous sample analysis with polymerase chain reaction, <i>A. baumannii</i> infection was diagnosed. The patient was treated with fortified topical colistin, amikacin, and subconjunctival and intravitreal colistin, which responded with the resolution of intraocular inflammation. This case emphasizes the therapeutic challenges of <i>A. baumannii</i> endophthalmitis. It highlights colistin as an effective treatment option in cases resistant to conventional regimens.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"15 1","pages":"15"},"PeriodicalIF":0.7000,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067959/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Research in Pharmacy Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jrpp.jrpp_72_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
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Abstract
Postoperative endophthalmitis is a rare but severe complication of phacoemulsification cataract surgery (PCS). Acinetobacter baumannii is an uncommon pathogen, often associated with multidrug resistance and poor outcomes. In this report, a 73-year-old male who developed endophthalmitis following PCS is introduced, who, despite intensive empirical therapy, experienced no clinical improvement. Following a vitreous sample analysis with polymerase chain reaction, A. baumannii infection was diagnosed. The patient was treated with fortified topical colistin, amikacin, and subconjunctival and intravitreal colistin, which responded with the resolution of intraocular inflammation. This case emphasizes the therapeutic challenges of A. baumannii endophthalmitis. It highlights colistin as an effective treatment option in cases resistant to conventional regimens.
期刊介绍：
The main focus of the journal will be on evidence-based drug-related medical researches (with clinical pharmacists’ intervention or documentation), particularly in the Eastern Mediterranean region. However, a wide range of closely related issues will be also covered. These will include clinical studies in the field of pharmaceutical care, reporting adverse drug reactions and human medical toxicology, pharmaco-epidemiology and toxico-epidemiology (poisoning epidemiology), social aspects of pharmacy practice, pharmacy education and economic evaluations of treatment protocols (e.g. cost-effectiveness studies). Local reports of medication utilization studies at hospital or pharmacy levels will only be considered for peer-review process only if they have a new and useful message for the international pharmacy practice professionals and readers.
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