Thunderstorm-Associated Asthma in Shenzhen, China: A Retrospective Case-Control Study of Risk Factors, Clinical Characteristics, and Management Approaches.

IF 3 3区医学 Q2 ALLERGY

Journal of Asthma and Allergy Pub Date : 2026-04-01 eCollection Date: 2026-01-01 DOI:10.2147/JAA.S584545

Xubin Shang, Yonggang Yang, Wangsheng Deng

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引用次数: 0

Abstract

Objective: To identify risk factors, clinical characteristics, and management approaches associated with thunderstorm-associated asthma (TA) in Shenzhen, China, comparing it with general asthma (GA).

Methods: A retrospective case-control study was conducted, including 42 patients with TA who presented with asthma exacerbations following thunderstorms and 361 patients with GA. Demographic variables and inflammatory biomarkers, including absolute eosinophil count (AEC), absolute neutrophil count, and C-reactive protein were evaluated. Logistic regression and receiver operating characteristic analyses were applied to determine discriminative factors.

Results: Patients with TA were younger than those with GA (median 49 vs 57 years, p = 0.003) and demonstrated a higher prevalence of allergic rhinitis (73.8% vs 41.0%, p < 0.001). Eosinophil counts were significantly elevated among patients with TA (0.74×10⁹/L vs 0.42×10⁹/L, p < 0.001). An AEC ≥ 0.71×10⁹/L effectively differentiated TA from GA (area under the curve [AUC] = 0.843). The combined model incorporating age, allergic rhinitis history, and AEC yielded improved diagnostic performance (AUC = 0.880). Hospitalization rates were lower in the TA group (16.7% vs 68.4%, p = 0.041), although all individuals received oxygen therapy.

Conclusion: TA in Shenzhen affects younger atopic individuals with eosinophilic inflammation. AEC ≥0.71×10⁹/L may aid screening during meteorological alerts, guiding acute management with oxygen, bronchodilators, and corticosteroids while avoiding unnecessary antibiotics.

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中国深圳雷暴相关哮喘：危险因素、临床特征和管理方法的回顾性病例对照研究。

目的：探讨中国深圳地区雷暴相关哮喘（TA）的危险因素、临床特征和治疗方法，并将其与普通哮喘（GA）进行比较。方法：采用回顾性病例对照研究，包括42例出现雷暴后哮喘加重的TA患者和361例GA患者。评估人口统计学变量和炎症生物标志物，包括绝对嗜酸性粒细胞计数（AEC）、绝对中性粒细胞计数和c反应蛋白。采用Logistic回归和受试者工作特征分析确定判别因素。结果：TA患者比GA患者年轻（中位49岁vs中位57岁，p = 0.003），变应性鼻炎的患病率更高（73.8% vs 41.0%, p < 0.001）。TA患者嗜酸性粒细胞计数显著升高（0.74×109/L vs 0.42×109/L, p < 0.001）。AEC≥0.71×109/L能有效区分TA与GA（曲线下面积[AUC] = 0.843）。结合年龄、变应性鼻炎病史和AEC的联合模型的诊断效果更好（AUC = 0.880）。TA组住院率较低（16.7% vs 68.4%, p = 0.041），尽管所有患者都接受了氧疗。结论：深圳TA多发于嗜酸性粒细胞炎症的年轻特应性个体。AEC≥0.71×109/L可能有助于在气象警报期间进行筛查，指导急性治疗时使用氧气、支气管扩张剂和皮质类固醇，同时避免不必要的抗生素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.