Stepwise oral food challenge test.

IF 2.8 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-10 DOI:10.1097/ACI.0000000000001149

Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa

{"title":"Stepwise oral food challenge test.","authors":"Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa","doi":"10.1097/ACI.0000000000001149","DOIUrl":null,"url":null,"abstract":"Purpose of review: The oral food challenge (OFC) remains the cornerstone procedure for diagnosing food allergies and guiding patient management. Recently, stepwise OFC, a new management strategy starting with very-low-dose (VLD) or low-dose OFC, has been reported. This review critically examines the clinical utility and safety profile of stepwise OFC approaches.Recent findings: The stepwise OFC typically begins with a VLD or low-dose OFC, which is the most critical step in this approach. VLD and low-dose OFCs have been demonstrated to be useful strategies for avoiding complete elimination of causative foods and improving prognosis. Regarding safety considerations, a time interval of 30 min between doses may be insufficient, whereas an interval of at least 1 h is considered appropriate for stepwise OFC.Summary: Stepwise OFCs starting with VLD or low-dose appear to be effective approaches. VLD and low-dose OFCs are well tolerated and effective for avoiding complete elimination of allergenic foods. VLD and low-dose OFCs, as part of stepwise OFC, represent useful strategies for improving the prognosis of children with food allergies.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"193-200"},"PeriodicalIF":2.8000,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Allergy and Clinical Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ACI.0000000000001149","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/4/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: The oral food challenge (OFC) remains the cornerstone procedure for diagnosing food allergies and guiding patient management. Recently, stepwise OFC, a new management strategy starting with very-low-dose (VLD) or low-dose OFC, has been reported. This review critically examines the clinical utility and safety profile of stepwise OFC approaches.

Recent findings: The stepwise OFC typically begins with a VLD or low-dose OFC, which is the most critical step in this approach. VLD and low-dose OFCs have been demonstrated to be useful strategies for avoiding complete elimination of causative foods and improving prognosis. Regarding safety considerations, a time interval of 30 min between doses may be insufficient, whereas an interval of at least 1 h is considered appropriate for stepwise OFC.

Summary: Stepwise OFCs starting with VLD or low-dose appear to be effective approaches. VLD and low-dose OFCs are well tolerated and effective for avoiding complete elimination of allergenic foods. VLD and low-dose OFCs, as part of stepwise OFC, represent useful strategies for improving the prognosis of children with food allergies.

查看原文本刊更多论文

逐步口腔食物激发试验。

综述目的：口腔食物激发（OFC）仍然是诊断食物过敏和指导患者管理的基石程序。最近，一种新的从极低剂量（VLD）或低剂量OFC开始的治疗策略——渐进式OFC被报道。这篇综述严格审查了渐进式OFC方法的临床应用和安全性。最近的发现：渐进式OFC通常从VLD或低剂量OFC开始，这是该方法中最关键的一步。VLD和低剂量OFCs已被证明是避免完全消除致病食物和改善预后的有效策略。考虑到安全性，剂量间隔30分钟可能是不够的，而对于逐步OFC，间隔至少1小时被认为是合适的。总结：从VLD或低剂量开始的逐步OFCs似乎是有效的方法。VLD和低剂量OFCs耐受性良好，可有效避免完全消除过敏性食物。作为逐步OFC的一部分，VLD和低剂量OFC代表了改善食物过敏儿童预后的有用策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.