Regio Selective Arylation and Synthesis of New Alkyl−/Aryl−/Hetero-3,6-di-Bromo-5-(Pyridine-4-yl)-1,4-Diazine-2-Carboxamidate Derivatives

Abstract

The heterocyclic scaffold natural products are abundant and widely scattered in nature, playing a vital role in human life, stirring up broad importance from scientists as they are accomplished of providing valuable properties. Among these, 6-membered 1,4-diazipene-2-carbaxamides have attracted considerable attention owing to their interesting and potent biological properties. In this article, we report the synthesis of several Pyrido-pyrazine-2-carboxamide (5a-l) analogs with an efficient procedure in good to excellent yields and with high regio-selectivity by chemical transformations. This is the first report on the preparation of pyridine-containing tetra-substituted pyrazine-2-carbaxamide skeletons synthetic route to get novel 3,6-dibromo-5-(pyridine-4-yl)-1,4-diazine-2-carbaxamide (5a-l) scaffolds to establish the current state of the art in this area.