Cryostructuring of Polymeric Systems. 71. Poly(vinyl alcohol) Cryogels Formed by Freezing–Defrosting of Concentrated Polymer Solutions in a Dimethyl Sulfoxide–Dimethylformamide Mixture

IF 1.1 4区化学 Q4 CHEMISTRY, PHYSICAL

Colloid Journal Pub Date : 2026-04-14 DOI:10.1134/S1061933X25601830

D. A. Michurov, V. G. Vasil’ev, V. I. Lozinsky

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Abstract

Noncovalent cryogels have been prepared via the cryotropic gelation of 100 g/L poly(vinyl alcohol) (PVA) solutions in dimethyl sulfoxide (DMSO) and its mixture with dimethylformamide (DMF) (75 : 25, vol/vol). The physicochemical characteristics of the cryogels have been determined for both freshly prepared (“primary”) samples and samples subjected to replacing organic dispersion media by water with the formation of hydrated (“secondary”) PVA cryogels. It has been shown that the elasticity moduli of the samples formed in the DMSO/DMF medium are significantly higher than those of the cryogels prepared in the DMSO medium. Moreover, the former gel matrices undergo a greater volumetric shrinkage during hydration in comparison with the latter cryogels. In addition, cryogels prepared in the DMSO/DMF medium are highly transparent. The kinetic study of releasing a model drug, ibuprofen sodium salt, from the “secondary” cryogels has shown the absence of significant diffusion hindrances for the release of this biologically active compound from the gel carriers.

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高分子体系的低温结构。71。聚乙烯醇在二甲基亚砜-二甲基甲酰胺混合物中的浓缩聚合物溶液冷冻-除霜形成的低温物

用100 g/L聚乙烯醇（PVA）溶液在二甲亚砜（DMSO）及其与二甲甲酰胺（DMF）（75∶25,vol/vol）的混合物中低温凝胶法制备了非共价冷冻液。对于新鲜制备的（“初级”）样品和用水取代有机分散介质形成水合（“次级”）聚乙烯醇冷冻的样品，已经确定了冷冻的物理化学特性。结果表明，在DMSO/DMF介质中形成的样品的弹性模量明显高于在DMSO介质中制备的低温样品。此外，前者凝胶基质在水化过程中经历更大的体积收缩与后者的冷冻。此外，在DMSO/DMF培养基中制备的冷冻液具有高透明度。从“二级”冷冻箱中释放模型药物布洛芬钠盐的动力学研究表明，这种生物活性化合物从凝胶载体中释放没有明显的扩散障碍。

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来源期刊

Colloid Journal 化学-物理化学

CiteScore

2.20

自引率

18.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Colloid Journal (Kolloidnyi Zhurnal) is the only journal in Russia that publishes the results of research in the area of chemical science dealing with the disperse state of matter and surface phenomena in disperse systems. The journal covers experimental and theoretical works on a great variety of colloid and surface phenomena: the structure and properties of interfaces; adsorption phenomena and structure of adsorption layers of surfactants; capillary phenomena; wetting films; wetting and spreading; and detergency. The formation of colloid systems, their molecular-kinetic and optical properties, surface forces, interaction of colloidal particles, stabilization, and criteria of stability loss of different disperse systems (lyosols and aerosols, suspensions, emulsions, foams, and micellar systems) are also topics of the journal. Colloid Journal also includes the phenomena of electro- and diffusiophoresis, electro- and thermoosmosis, and capillary and reverse osmosis, i.e., phenomena dealing with the existence of diffusion layers of molecules and ions in the vicinity of the interface.