Rethinking aortic stenosis quantification: from linear assumptions to sigmoid reality-critical considerations for clinical translation.

IF 4.1 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Sachiko Kanki
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引用次数: 0
重新思考主动脉狭窄量化:从线性假设到乙状结肠现实-临床翻译的关键考虑。
在这一期的《心脏与循环生理学》杂志上,Buffle及其同事介绍了一种范式转换方法,通过他们的新参数,主动脉瓣相对刚度(rAVS)来评估主动脉瓣狭窄(AS),该参数来源于流面积关系的s型模型[1]。通过挑战当前诊断算法中长期存在的线性假设,这项工作提供了一种与流量无关的指标,可以消除压力测试的需要,同时提供更好的预后区分。然而,在广泛的临床应用之前,关于模型的普遍性、对特定瓣膜类型的适用性以及异常循环状态在模型验证中的作用的几个关键问题需要仔细考虑。这篇社论审查了该研究的主要贡献,并提出了必须解决的基本问题,以便将该研究转化为现实世界的临床实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.60
自引率
10.40%
发文量
202
审稿时长
2-4 weeks
期刊介绍: The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. The journal embraces new descriptions of these functions and their control systems, as well as their basis in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new mechanistic physiological insights that determine the performance of the normal and abnormal heart and circulation.
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