Outcomes after surgical correction of severe scoliosis in patients with osteogenesis imperfecta: a prospective, 2-year minimum follow-up study with radiographic and patient-reported outcomes.

IF 1.7 Q3 CLINICAL NEUROLOGY

Spine deformity Pub Date : 2026-09-01 Epub Date: 2026-04-09 DOI:10.1007/s43390-026-01340-y

Satoshi Takada, Suken A Shah, Hiroshi Taneichi, Yusuke Hori, Petya K Yorgova, Andrea Elsby, Tyler C McDonald, Richard W Kruse, Jeanne M Franzone

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引用次数: 0

Abstract

Purpose: To evaluate both radiographic and patient-reported outcomes after surgical correction of severe scoliosis in osteogenesis imperfecta (OI) patients with minimum 2-year follow-up. The main research question was whether modern multimodal surgical approaches translate into meaningful improvements in both deformity correction and quality of life measures.

Methods: This retrospective analysis of prospectively collected data included 35 OI patients (mean age 12.2 ± 3.7 years) who underwent posterior spinal fusion for scoliosis at a single institution between 2013 and 2022. OI type 3 was most common (69%). Radiographic parameters and patient-reported outcomes (SRS-22, CP CHILD, PROMIS) were assessed preoperatively and at latest follow-up (mean 5.5 ± 3.1 years). Surgical technique included navigation-guided pedicle screw placement, cement augmentation at foundation levels, and perioperative bisphosphonate therapy.

Results: Major curve improved from 72.3 ± 15° to 32.2 ± 17° (56% correction, p < 0.001) and minor curve from 53.8 ± 14° to 24.1 ± 12° (55% correction, p < 0.001). Other radiographic parameters including apical vertebral translation, lowest instrumented vertebra tilt, pelvic obliquity, and thoracolumbar kyphosis showed significant improvement while maintaining thoracic kyphosis and lumbar lordosis. SRS-22 total score improved from 3.6 to 4.1 (p = 0.002), with function, pain, and self-image domains achieving minimal clinically important differences. CP CHILD total score improved, with significant improvement in the positioning/transferring/mobility domain. PROMIS showed significant improvements in fatigue and pain interference. Two complications (5.7%) occurred without infections or neurological deficits.

Conclusion: Modern surgical correction of severe scoliosis in OI patients achieved significant improvements in both radiographic parameters and patient-reported outcomes, demonstrating the effectiveness of current multimodal surgical strategies in this challenging population.

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成骨不全患者重度脊柱侧凸手术矫正后的结果：一项前瞻性、2年最少随访研究，包括影像学和患者报告的结果。

目的：通过至少2年的随访，评估成骨不全（OI）患者的严重脊柱侧凸手术矫正后的影像学和患者报告的结果。主要的研究问题是现代多模式手术方法是否在畸形矫正和生活质量方面都有意义的改善。方法：回顾性分析前瞻性收集的数据，包括2013年至2022年在同一机构接受后路脊柱融合术治疗脊柱侧凸的35例成骨不全症患者（平均年龄12.2±3.7岁）。3型成骨不全最为常见（69%）。术前和最新随访时（平均5.5±3.1年）评估影像学参数和患者报告结果（SRS-22、CP CHILD、PROMIS）。手术技术包括导航引导椎弓根螺钉置入、基础水平水泥增强和围手术期双磷酸盐治疗。结果：主曲线从72.3±15°改善到32.2±17°（矫正率56%，p）。结论：OI患者严重脊柱侧凸的现代手术矫正在影像学参数和患者报告的结果方面均取得了显著改善，证明了当前多模式手术策略在这一具有挑战性的人群中的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Spine deformity

CiteScore

3.20

自引率

18.80%

发文量

167

期刊介绍： Spine Deformity the official journal of the?Scoliosis Research Society is a peer-refereed publication to disseminate knowledge on basic science and clinical research into the?etiology?biomechanics?treatment?methods and outcomes of all types of?spinal deformities. The international members of the Editorial Board provide a worldwide perspective for the journal's area of interest.The?journal?will enhance the mission of the Society which is to foster the optimal care of all patients with?spine?deformities worldwide. Articles published in?Spine Deformity?are Medline indexed in PubMed.? The journal publishes original articles in the form of clinical and basic research. Spine Deformity will only publish studies that have institutional review board (IRB) or similar ethics committee approval for human and animal studies and have strictly observed these guidelines. The minimum follow-up period for follow-up clinical studies is 24 months.