Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons.

IF 2.8 3区生物学 Q3 CELL BIOLOGY

Traffic Pub Date : 2026-06-01 DOI:10.1111/tra.70034

Beatriz Aznar-Escolano, Vera Egorova, José Villanueva, Luis Miguel Gutiérrez, Virginia González-Vélez, Amparo Gil, Sandra Jurado

引用次数: 0

Abstract

Oxytocin plays a critical role in social behavior and maternal physiology, yet the intracellular dynamics of oxytocin-containing vesicles in neurons remain poorly characterized. Here, we combine experimental data from live cell imaging of oxytocin-containing compartments with computational analysis to investigate their mobility within hypothalamic neurons. Using machine learning-based trajectory classification, we reveal that the majority of oxytocin compartments exhibit subdiffusive motion, suggesting constraints imposed by the complex intracellular environment. This behavior likely reflects interactions with cytoskeletal structures, vesicle maturation states, or localized functional demands. Our findings provide new insights into the intracellular trafficking of neuropeptides and highlight the utility of data-driven approaches for uncovering mechanisms of neurophysiological relevance.

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揭示下丘脑神经元中催产素的动态。

催产素在社会行为和母体生理中起着至关重要的作用，然而，神经元中含有催产素的囊泡的细胞内动力学仍然缺乏表征。在这里，我们将含有催产素的室室的活细胞成像实验数据与计算分析相结合，以研究它们在下丘脑神经元内的流动性。使用基于机器学习的轨迹分类，我们发现大多数催产素室表现出亚扩散运动，这表明复杂的细胞内环境施加了约束。这种行为可能反映了细胞骨架结构、囊泡成熟状态或局部功能需求的相互作用。我们的发现为神经肽的细胞内运输提供了新的见解，并强调了数据驱动方法在揭示神经生理学相关机制方面的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Traffic 生物-细胞生物学

CiteScore

8.10

自引率

2.20%

发文量

审稿时长

2 months

期刊介绍： Traffic encourages and facilitates the publication of papers in any field relating to intracellular transport in health and disease. Traffic papers span disciplines such as developmental biology, neuroscience, innate and adaptive immunity, epithelial cell biology, intracellular pathogens and host-pathogen interactions, among others using any eukaryotic model system. Areas of particular interest include protein, nucleic acid and lipid traffic, molecular motors, intracellular pathogens, intracellular proteolysis, nuclear import and export, cytokinesis and the cell cycle, the interface between signaling and trafficking or localization, protein translocation, the cell biology of adaptive an innate immunity, organelle biogenesis, metabolism, cell polarity and organization, and organelle movement. All aspects of the structural, molecular biology, biochemistry, genetics, morphology, intracellular signaling and relationship to hereditary or infectious diseases will be covered. Manuscripts must provide a clear conceptual or mechanistic advance. The editors will reject papers that require major changes, including addition of significant experimental data or other significant revision. Traffic will consider manuscripts of any length, but encourages authors to limit their papers to 16 typeset pages or less.